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(A) Æú¸®ÆéŸÀ̵å(polypeptide) È£¸£¸ó¡¤´Ü¹éÁú È£¸£¸ó°ú ±Û¸®ÄÚÇÁ·ÎÅ×ÀÎ(glycoprotein) È£¸£¸ó°ú ±× À¯µµÃ¼¿Í ±¸Á¶ÀûÀ¸·Î À¯»çÇÑ °Í
¿©±â¿¡´Â ƯÈ÷ ´ÙÀ½ÀÇ °ÍÀ» Æ÷ÇÔÇÑ´Ù.

(1) ¼ºÀåÈ£¸£¸ó¡¤À̵éÀÇ À¯µµÃ¼¿Í ±¸Á¶ÀûÀÎ À¯»çü : ¼ºÀå È£¸£¸ó[¼ºÀå È£¸£¸ó, GH, STH(¼ºÀåÈ£¸£¸ó)] : Á¶Á÷üÀÇ ¼ºÀåÀ» ÃËÁø½ÃÅ°´Â ±×¸®°í ´Ü¹éÁú ½ÅÁø´ë»çÀÇ ´Ù¸¥ ¹ÝÀÀµéÀÇ Á¶Àý°ú °ü·ÃÀÌ ÀÖ´Â ¹°¿¡ ³ì´Â ´Ü¹éÁú¡¤³úÇϼöü Àü¿±ÀÇ ¼ºÀå¼¼Æ÷¿¡ ÀÇÇØ ºÐºñµÈ´Ù. ºÐºñ´Â ºÐºñ ¿ä¼Ò(¼ºÀåÈ£¸£¸ó-ºÐºñÈ£¸£¸ó)¿Í ¾ïÁ¦ ¿ä¼ÒÀÎ ¼Ò¸¶Å佺ŸÀÎ(¼ºÀå¾ïÁ¦È£¸£¸ó)¿¡ ÀÇÇØ Á¶ÀýµÈ´Ù. ¼ºÀåÈ£¸£¸ó(hGH)Àº 191°³ÀÇ ¾Æ¹Ì³ë»ê Áß ´ëºÎºÐ À¯ÀüÀÚ ÀçÁ¶ÇÕ DNA±â¼ú¿¡ ÀÇÇؼ­¸¸ ¸¸µç ´Ü ÇϳªÀÇ Æú¸®ÆéƼµå(polypeptide) °í¸®ÀÌ´Ù. ÀÌ ºÎºÐÀº ¶ÇÇÑ À¯µµÃ¼¿Í ¼Ò¸¶Æ®·½(somatrem)(INN)(¸ÞƼ¿À´Ò hGH)¡¤¾Æ¼¼Æ¿È­ hGH¡¤Å»¾Æ¹Ì³ë hGH¿Í ¼Ò¸Þ³ëÆ÷¸£(somenopor)(INN)¿Í °°Àº À¯»çü¿Í Æä±×ºñ¼Ò¸ÕÆ®(pegvisomant)(INN)¿Í °°Àº È£¸£¸ó¹æÁöÁ¦(hormone antagonist)¸¦ Æ÷ÇÔÇÑ´Ù.

(2) Àν¶¸°(insulin)°ú ±× ¿°(salt) : Àν¶¸°Àº 51°³ÀÇ ¾Æ¹Ì³ë»ê ±×·ìÀ» ÇÔÀ¯ÇÏ´Â Æú¸®ÆéƼµå(polypeptide)ÀÌ¸ç ¸¹Àº µ¿¹°µé ÃéÀåÀÇ ¶û°Ô¸£Çѽº¼¶(islet of Langerhans)¿¡¼­ ¸¸µé¾îÁø´Ù. Àΰ£ÀÇ Àν¶¸°Àº ÀçÁ¶ÇÕµÈ Àΰ£ Àν¶¸°À» ¸¸µé±â À§ÇØ ÃéÀå¿¡¼­ ÃßÃâÇϰųª ¼Ò³ª µÅÁöÀÇ Àν¶¸°À» º¯ÇüÇÔÀ¸·Î ȤÀº ¹ÚÅ׸®¾Æ³ª È¿¸ð¿Í °ü·ÃµÈ »ý¹°°øÇÐÀûÀÎ °úÁ¤µéÀ» ÅëÇØ ¾òÀ» ¼ö ÀÖ´Ù. Àν¶¸°Àº ¼øȯÇÏ´Â Æ÷µµ´ç°ú ±× ¹ÛÀÇ ¿µ¾ç¼Ò¸¦ ±Û¸®ÄÚ°Õ°ú Áö¹æ ÇüÅ·ΠÀúÀåÇÒ »Ó¸¸ ¾Æ´Ï¶ó ¼¼Æ÷ÁúÀÇ ±× ¼·Ãë¿¡ ÀÖ¾î ÇϳªÀÇ ¿ä¼ÒÀÌ´Ù. ¼ø¼ö Àν¶¸°Àº Èò»öÀÇ Èí½À¼ºÀÌ ¾ø´Â ºñ°áÁ¤ÁúÀÇ °¡·ç ȤÀº ¼ö¿ë¼ºÀÇ ±¤ÅÃÀÌ ÀÖ´Â °áÁ¤Ã¼ÀÌ´Ù. ÀÌ°ÍÀº ´ç´¢º´ Ä¡·á¿¡ ¾²ÀδÙ. Àν¶¸°¿°Àº ¿°»ê Àν¶¸°À» Æ÷ÇÔÇÑ´Ù.

(3) ºÎ½ÅÇÇÁúÀÚ±ØÈ£¸£¸ó(corticotropin)(INN)[¾Æµå·¹³ëÄÚ¸£Æ¼ÄÚÆ®·ÎÇÈ È£¸£¸ó(ACTH : adreno
corticotropic hormone)¡¤¾Æµå·¹³ëÄÚ¸£Æ¼ÄÚÆ®·ÎÇÉ] : ¹°¿¡ ³ì´Â Æú¸® ÆéŸÀ̵å·Î¼­ ¾Æµå·¹³ëÄÚ¸£Æ¼Ä® ½ºÅ×·ÎÀ̵åÀÇ »ý¼ºÀ» ÀÚ±ØÇÑ´Ù. Áö·¢Æ¼µå(Giractide)(INN)µµ ºÎ½ÅÇÇÁúÀÚ±ØÈ£¸£¸óÀÇ À¯»ç¹°ÁúÀÌ´Ù.

(4) À¯ÁóºÐºñÈ£¸£¸ó(lactogenic hormone : LTH¡¤°¥¶ôƾ¡¤°¥¶ôÅäÁø È£¸£¸ó¡¤·çÅ׿ÀÆ®·ÎÇÉ¡¤¸¶¸ðÆ®·ÎÇÉ¡¤ÇÁ·Î¶ôƾ) : °áÁ¤¼ºÀÇ Æú¸®ÆéŸÀ̵å(polypeptide)·Î¼­ À¯ÁóºÐºñ(êáñðÝÂÝô : milk secretion)ÀÛ¿ëÀ» ÃËÁøÇÏ°í Ç×ü(corpus luteum)ÀÇ È°¼º¿¡ ¿µÇâÀ» ÁØ´Ù.

(5) °©»ó¼±ÀÚ±ØÈ£¸£¸ó(thyrotrophin)(INN)(Ƽ·ÎÆ®·ÎÇÈ È£¸£¸ó¡¤TSH : thyroid-stimulating hormone) : Ç÷¾× ÁßÀÇ °©»ó¼± ÀÛ¿ë°ú ¿ä¿ÀµåÀÇ À̵¿¿¡ °ÔÀçÇÏ´Â ´ç´Ü¹éÁú(glycoprotein)ÀÌ´Ù. ¼ºÀå°ú ºÐºñ¿¡ ¿µÇâÀ» ¹ÌÄ£´Ù.

(6) ³­Æ÷ÀÚ±ØÈ£¸£¸ó(follicle-stimulating hormone : FSH) : ´ç´Ü¹éÁúÀ¸·Î¼­ ¹°¿¡ ³ìÀ¸¸ç ¼º±â´ÉÀ» ÀڱؽÃŲ´Ù.

(7) ȲüÇü¼ºÈ£¸£¸ó[luteinising hormone : LH¡¤(Á¶Á÷ »çÀÌÀÇ ¼¼Æ÷ÀÚ±Ø È£¸£¸ó)(ICSH : interstitial-cell-stimulating hormone), ·çÅ×À̳뽺Ƽ¹Ä¸°] : ¼ö¿ë¼º±Û¸®ÄÚÇÁ·ÎÅ×ÀΡ¤½ºÅ×·ÎÀÌµå ºÐºñ¿Í ¹è¶õ°ú Á¶Á÷ »çÀÌÀÇ ¼¼Æ÷Çü¼ºÀ» ÃËÁøÇϸ鼭 ¼º±â´ÉÀ» ÀÚ±ØÇÑ´Ù.

(8) À¶¸ð¸·(chorionic) °í³ªµµÆ®·ÎÇÉ(INN)(hCG : »ç¶÷ À¶¸ð¼º ¼º¼± ÀÚ±ØÈ£¸£¸ó) : ÅÂ¹Ý Áß¿¡¼­ »ý¼ºµÇ´Â ´ç´Ü¹éÁú(glycoprotein)À¸·Î¼­ ÀÓ»êºÎÀÇ ¼Òº¯¿¡¼­ ÃßÃâµÈ´Ù. ¹é»ö °áÁ¤Ã¼·Î¼­ ±× ¼ö¿ë¾×Àº ºÒ¾ÈÁ¤ÇÏ¸ç ³­Æ÷ÀÇ ¼º¼÷À» ÀڱؽÃŲ´Ù.

(9) Ç÷û°í³ªµµÆ®·ÎÇÉ(INN)(eCG : ¸»ÀÇ À¶¸ð¼º ¼º¼± ÀÚ±Ø È£¸£¸ó) : »ý½Ä¼± ÀÚ±ØÀÛ¿ëÀ» ÇÏ´Â ´ç´Ü¹éÁú(glycoprotein)À¸·Î¼­ ÀÓ½ÅÇÑ ¸»ÀÇ Å¹ݰú Àڱ󻸷¿¡¼­ »ý¼ºµÈ´Ù. º»·¡ ÀÓ½ÅÇÑ ¸»ÀÇ Ç÷û°í³ªµµÆ®·ÎÇÉÀ¸·Î ºÒ¸°´Ù.

(10) ¿Á½ÃÅä½Å(oxytocin)(INN)[¾ËÆÄ(¥á)-È÷Æ÷ÆĹÎ] : Æú¸®ÆéŸÀ̵å(polypeptide)·Î¼­ ¹°¿¡ ³ìÀ¸¸ç ÁÖ·Î Àڱà ¼öÃà°ú À¯¼±ÀÇ À¯ºÐÃâ ÀÛ¿ëÀ» ÇÑ´Ù. ¶ÇÇÑ Ä«¸£º£Åä½Å(carbetocin)(INN)¡¤µ¥¸ñ½ÃÅä½Å(demoxytocin)(INN) µîÀÇ À¯»ç ¹°Áúµµ Æ÷ÇÔÇÑ´Ù.

(11) Ç÷°ü¼öÃàÈ£¸£¸ó(vasopressin) : ¾Æ¸£±âÇÁ·¹½Å(INN)°ú ¸®ÇÁ·¹½Å(INN)¡¤±× À¯µµÃ¼¿Í À¯»çÇÑ ±¸Á¶¸¦ °¡Áø ¹°Áú¡¤Ç÷°ü¼öÃàÈ£¸£¸óÀº Æú¸®ÆéŸÀ̵å(polypeptide)·Î¼­ Ç÷¾Ð»ó½ÂÀÛ¿ë°ú ÄáÆÏÀÇ º¸¼ö·Â Áõ°¡ÀÛ¿ëÀ» ÇÑ´Ù. ¶ÇÇÑ Å׸£¸®ÇÁ·¹½Å(terlipressin)(INN)¡¤µ¥½º¸ðÇÁ·¹½Å(desmopressin)(INN)°ú °°Àº Æú¸®ÆéŸÀ̵å(polypeptide) À¯»ç¹°Áúµµ Æ÷ÇÔÇÑ´Ù.

(12) Ä®½ÃÅä´Ñ(calcitonin)(INN)(TCA : Ƽ·ÎÄ®½ÃÅä´Ñ) : Æú¸®ÆéŸÀ̵å(polypeptide)·Î¼­ Ç÷¾× Áß Æ÷µµ´çÀÇ ³óµµ¸¦ Áõ°¡½ÃÅ°´Â Ư¼ºÀÌ ÀÖ´Ù.

(13) ±Û·çÄ«°ï(glucagon)(INN)(HGF : ÇÏÀÌÆÛ±Û¸®¼¼¹Í-±Û¸®ÄڰԳ븮ƽ ÀÎÀÚ) : Æú¸®ÆéŸÀ̵å·Î¼­ Ç÷¾× Áß Æ÷µµ´çÀÇ ³óµµ¸¦ Áõ°¡½ÃÅ°´Â Ư¼ºÀÌ ÀÖ´Ù.

(14) Ƽ·Ñ¸®º£¸°(thyroliberin)(TRF¡¤TRH) : Æú¸®ÆéŸÀ̵å·Î¼­ Ƽ·ÎÆ®·ÎÇÉ(thyrotropin)ÀÇ ºÐºñ¸¦ ÀڱؽÃŲ´Ù.

(15) °í³ªµµ·¼¸°(gonadorelin)(INN)(°í³ªµµ¸±º£¸°¡¤°í³ªµµÆ®·ÎÇÉ ÀÚ±ØÈ£¸£¸ó¡¤LRF¡¤GnRH) : Æú¸®ÆéŸÀ̵å·Î¼­ ³úÇϼö¼±¿¡¼­ ³­Æ÷¿Í Ȳü ÀÚ±Ø È£¸£¸óÀÇ ºÐºñ¸¦ ÃËÁø½ÃŲ´Ù. ¶ÇÇÑ Æú¸®ÆéŸÀ̵å À¯»ç¹°Áú ºÎ¼¼¸±¸°(buserilin)(INN)¡¤°í¼¼¸±¸°(goserilin)(INN)¡¤Æ丣Ƽ·¼¸°(fertirelin)
(INN) ¡¤¼¼¸£¸ð·¼¸°(sermorelin)(INN) µîµµ Æ÷ÇÔÇÑ´Ù.

(16) ¼Ò¸¶Å佺Ÿƾ(somatostatin)(INN)(SS¡¤SRIH¡¤SRIF) : Æú¸®ÆéŸÀ̵å·Î¼­ ³úÇϼö¼±À¸·ÎºÎÅÍ ¼ºÀåÈ£¸£¸ó°ú TSHÀÇ ¹æÃâÀ» ¾ïÁ¦ÇÏ¸ç ½Å°æģȭÀÛ¿ëÀ» ÇÑ´Ù.

(17) ½É¹æ¼º ³ªÆ®·ýÀÌ´¢ È£¸£¸ó(atrial natriuretic hormone : ANH¡¤ANF) : ½ÉÀåÀÇ ½É¹æ¿¡¼­ºÎÅÍ ºÐºñµÇ´Â Æú¸®ÆéƼµå È£¸£¸óÀÌ´Ù. Ç÷¾×ÀÇ ºÎÇÇ°¡ Áõ°¡ÇÏ¿© ½ÉÀåÀÇ ½É¹æÀÌ È®ÀåµÉ ¶§ ANH°¡ ºÐºñµÇµµ·Ï ÀڱصȴÙ. ±× ´ÙÀ½ ANH´Â ¼Ò±Ý°ú ¹°ÀÇ ¹è¼³À» Áõ°¡½ÃÅ°°í Ç÷¾ÐÀ» °¨¼Ò½ÃŲ´Ù.

(18) ¿£µµÅÚ¸°(endothelin) : ¸Æ°ü ±¸Á¶ Àüü¿¡ ÆÛÁ® ÀÖ´Â ³»ÇǼ¼Æ÷¿¡¼­ ºÐºñµÇ´Â Æú¸®ÆéƼµå È£¸£¸óÀÌ´Ù. ¿£µµÅÚ¸°ÀÌ ¼øȯµÇ´Â Ç÷¾×À¸·Î ¹æÃâµÈ´Ù ÇÒÁö¶óµµ, ±×°ÍÀº ÃøºÐºñ(ö°ÝÂù² : paracrine) °æÇâ¿¡ ÀÇÇØ ÀÎÁ¢ÇÑ Ç÷°üÀÇ ÆòÈ°±ÙÀ» ¼öÃàÇϵµ·Ï ±×¸®°í Ç÷¾ÐÀ» Áõ°¡ ½ÃÅ°µµ·Ï ±¹ºÎÀûÀ¸·Î È°µ¿ÇÑ´Ù.

(19) ÀÎÈ÷ºó(inhibin)°ú ¾×Ƽºó(activin) : »ý½Ä¼±(gonadal) Á¶Á÷¿¡¼­ ¹ß°ßµÇ´Â È£¸£¸óÀÌ´Ù.

(20) ·¾Æ¾(leptin) : Æú¸®ÆéŸÀ̵å È£¸£¸óÀ¸·Î¼­ ³úÀÇ ¼ö¿ëü¿¡¼­ ½Åü Áß·®°ú Áö¹æ ħÂøÀ» Á¶ÀýÇÏ´Â ¿ªÇÒÀ» ÇÏ´Â °ÍÀ¸·Î ¹Ï¾îÁö´Â Áö¹æ Á¶Á÷¿¡ ÀÇÇØ »ý»êµÈ´Ù. ¶ÇÇÑ ¿©±â¿¡´Â ·¾Æ¾ÀÇ ÀçÁ¶ÇÕ ¸ÞƼ¿À´Ò À¯µµÃ¼ÀÎ ¸ÞÆ®·¹·¾Æ¾(metreleptin)(INN)ÀÌ Æ÷ÇԵǴµ¥, ÀÌ´Â ·¾Æ¾ÀÇ À¯»çü·Î °£ÁÖÇÏ¸ç ·¾Æ¾°ú À¯»çÇÑ È°µ¿À» ÇÑ´Ù.

(B) ½ºÅ×·ÎÀ̵å È£¸£¸ó¡¤±× À¯µµÃ¼¿Í ±¸Á¶Àû À¯»çü

(1) ÄÚ¸£Æ¼ÄÚ½ºÅ×·ÎÀ̵å(corticosteroid) È£¸£¸ó : ºÎ½ÅÇÇÁúÀÇ ¿ÜÇÇ¿¡¼­ ºÐºñµÇ¾î ÀÎüÀÇ ½ÅÁø´ë»ç¸¦ À§ÇØ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù. ±×°ÍµéÀº ºÎ½ÅÇÇÁú È£¸£¸ó°ú ÄÚ¸£Æ¼ÄÚÀ̵å¶ó°í ¾Ë·ÁÁ® ÀÖÀ¸¸ç ÀϹÝÀûÀ¸·Î ±×µéÀÇ »ý¸®Àû ÀÛ¿ë¿¡ µû¶ó µÎ ±×·ìÀ¸·Î ³ªÀ§¾îÁø´Ù. Áï (¥¡) ´Ü¹éÁú°ú ź¼öÈ­¹°ÀÇ ´ë»ç ÀÛ¿ëÀ» Á¶ÀýÇÏ´Â ´çÁú ºÎ½ÅÇÇÁú È£¸£¸ó°ú (¥¢) ÀÎüÀÇ ³ªÆ®·ý°ú ¹°À» À¯ÁöÇÏ°í Ä®·ýÀÇ ¹è¼³ ÃËÁøÇÏ´Â ÀüÇØÁú ºÎ½ÅÇÇÁú È£¸£¸óÀÌ ÀÖ´Ù. ÀüÇØÁú ºÎ½ÅÇÇÁú È£¸£¸óÀÇ Æ¯Â¡Àº ¿¡µð½¼º´À̳ª ÄáÆÏ °áÇÌÀÇ Ä¡·á¿¡ ÀÌ¿ëµÈ´Ù. À̵éÀº ¾Æ·¡ÀÇ ÄÚ¸£Æ¼ÄÚ½ºÅ×·ÎÀ̵å È£¸£¸ó¡¤À¯µµÃ¼¿Í À¯»çüµéÀ» Æ÷ÇÔÇÑ´Ù.

(a) ÄÚ¸£Æ¼¼Õ(cortisone)(INN)*: ´Ü¹éÁú°ú ź¼öÈ­¹° ´ë»ç ÀÛ¿ëÀ» Á¶ÀýÇÏ°í ¶ÇÇÑ ±¹ºÎÀûÀÎ ¼Ò¿°ÀÛ¿ëÀ» ÇÏ´Â ´çÁú ºÎ½ÅÇÇÁú È£¸£¸ó

(b) È÷µå·ÎÄÚ¸£Æ¼¼Õ(hydrocortisone)(INN)(ÄÚ¸£Æ¼Á¹)* : ÄÚ¸£Æ¼¼Õ°ú À¯»çÇÑ ÀÛ¿ëÀ» ÇÏ´Â ´çÁú ºÎ½ÅÇÇÁú È£¸£¸ó

(c) ÇÁ·¹µå´Ï¼Õ(prednisone)(INN)(Å»È÷µå·ÎÄÚ¸£Æ¼¼Õ) : ´çÁú ºÎ½ÅÇÇÁú È£¸£¸ó¡¤ÄÚ¸£Æ¼¼ÕÀÇ À¯µµÃ¼

(d) ÇÁ·¹µå´Ï¼Ö·Ð(prednisolone)(INN)(Å»È÷µå·ÎÈ÷µå·ÎÄÚ¸£Æ¼¼Õ) : ´çÁú ¼ö½ÅÇÇÁú È£¸£¸ó¡¤È÷µå·ÎÄÚ¸£Æ¼¼ÕÀÇ À¯µµÃ¼

(e) ¾Ëµµ½ºÅ×·Ð(aldosterone)(INN) : ÀüÇØÁú ºÎ½ÅÇÇÁú È£¸£¸ó

(f) ÄÚ¸£Å䵶¼Õ(cortodoxone)(INN)
¸î¸î À¯µµÃ¼´Â À̵éÀÇ Ç׿° ÀÛ¿ë¿¡ µµ¿òÀÌ µÇµµ·Ï À̵éÀÇ ÇÇÁö È£¸£¸ó ¿µÇâÀ» ¾ïÁ¦½ÃÅ°±â À§ÇØ º¯ÇüµÇ¸ç ±×°ÍÀº È£¸£¸ó ÀÛ¿ëÀ¸·Î °£ÁÖµÉ °ÍÀÌ´Ù. À̰͵éÀº ÁÖ·Î ÄÚ¸£Æ¼¼Õ(cortisone)(INN)¡¤È÷µå·ÎÄÚ¸£Æ¼¼Õ(hydrocortisone)(INN)¡¤ÇÁ·¹µå´Ï¼Õ(prednisone)(INN)°ú ÇÁ·¹µå´Ï¼Ö·Ð(prednisolone)(INN)ÀÇ À¯µµÃ¼µéÀÌ´Ù. À̰͵éÀº Ç׿°°ú Ç×·ù¸ÓƼÁòÁ¦·Î »ç¿ëÇÑ´Ù.

(2) ÄÚ¸£Æ¼ÄÚ½ºÅ×·ÎÀ̵å(corticosteroid) È£¸£¸óÀÇ ÇҷΰÕÈ­ À¯µµÃ¼ : ÀϹÝÀûÀ¸·Î °í³­ ¸µ(gonane ring)ÀÇ 6 À̳ª 9 À§Ä¡¿¡¼­ ¼ö¼Ò¿øÀÚ´Â ¿°¼Ò³ª ºÒ¼Ò ¿øÀÚ[¿¹¸¦ µé¸é, µ¦»ç¸ÞŸÁ¸(dexamethasone)(INN)]¿¡ ÀÇÇؼ­ ´ëüµÇ°í ´çÁú ºÎ½ÅÇÇÁúÈ£¸£¸ó(ÄÚ¸£Æ¼ÄÚÀ̵å)°ú À̰͵鿡¼­ À¯µµµÈ ÄÚ¸£Æ¼ÄÚÀ̵åÀÇ ¼Ò¿°ÀÛ¿ëÀ» Å©°Ô ³ôÀÌ´Â ½ºÅ×·ÎÀ̵åÀÌ´Ù. ÀÌ À¯µµÃ¼µéÀº ¿¡½ºÅ׸£¿Í ¾Æ¼¼Å䳪À̵å[¿¹¸¦ µé¸é, Ç÷ç¿À½Ã³ë·Ð ¾Æ¼¼Åä´Ïµå(fluocinolone acetonide)(INN)] µîÀÇ ÇüÅ·ΠÁ¾Á¾ ´õ º¯ÇüµÇ¾î ÆǸŵȴÙ.

(3) ¿¡½ºÆ®·Î°Õ(oestrogen)°ú ÇÁ·Î°Ô½ºÅä°Õ(progestogen) : À̵éÀº ³²¼º°ú ¿©¼º »ý½Ä±âµé¿¡ ÀÇÇؼ­ ºÐºñµÇ´Â ¼º È£¸£¸óµé ÁßÀÇ ÁÖ¿äÇÑ µÎ ±×·ìÀÌ´Ù. À̰͵éÀº ÇÕ¼ºÇÔÀ¸·Î½á ¾òÀ» ¼ö ÀÖ´Ù. ÀÌ È£¸£¸óÀº ÇÁ·Î°Ô½ºÆ¾°ú °Ô½ºÅ¸°ÕÀ¸·Î ºÒ¸°´Ù.
¿¡½ºÆ®·Î°Õ(oestrogen) : ³­¼Ò¡¤°íȯ¡¤ºÎ½Å¡¤ÅÂ¹Ý ±×¸®°í ´Ù¸¥ ½ºÅ×·ÎÀ̵带 »ý¼ºÇÏ´Â Á¶Á÷µé¿¡ ÀÇÇؼ­ »ý¼ºµÇ´Â ¿©¼º È£¸£¸óÀÌ´Ù. ±×°ÍÀº ¾ÏÄÆ Æ÷À¯µ¿¹°¿¡¼­ ¹ßÁ¤Çϵµ·Ï Çϴ Ư¡ÀÌ ÀÖ´Ù. ¿¡½ºÆ®·Î°ÕÀº ¿©¼º¼ºµéÀÌ ¹ßÇöµÇ°Ô ÇÏ°í Æó°æ±â Ä¡·áÁ¦³ª ÇÇÀÓ¾àÀÇ Á¶Á÷Ç¥º»À¸·Î »ç¿ëÇÑ´Ù. À̰͵éÀº ¾Æ·¡ÀÇ ¿¡½ºÆ®·Î°Õ¡¤À¯µµÃ¼ ±×¸®°í À¯»çü¸¦ Æ÷ÇÔÇÑ´Ù.

(a) ¿¡½ºÆ®·Ð(estrone)(INN) : Àΰ£ÀÇ ÁÖ¿äÇÑ ¿¡½ºÆ®·Î°Õ

(b) ¿¡½ºÆ®¶óµð¿Ã(estradiol)(INN) : Áß¿äÇÑ Ãµ¿¬ ¿¡½ºÆ®·Î°Õ

(c) ¿¡½ºÆ®¸®¿Ã(estriol)(INN) : ÀÚ¿¬ ¿¡½ºÆ®·Î°Õ

(d) ¿¡Æ¼´Ò ¿¡½ºÆ®¶óµð¿Ã(ethinyl estradiol)(INN) : ÀÔÀ» ÅëÇؼ­ È°µ¿¼ºÀÌ ÀÖ°í Á¶ÇÕ ±¸°­ ÇÇÀӾ࿡¼­ ÁÖ¿ä ¿¡½ºÆ®·Î°Õ ¼ººÐÀ¸·Î »ç¿ëÇÏ´Â Áß¿äÇÑ ÇÕ¼º ¿¡½ºÆ®·Î°Õ

(e) ¸Þ½ºÆ®¶ó³î(mestranol)(INN) : ¿¡Æ¼´Ò ¿¡½ºÆ®¶óµð¿Ã(ethinyl estradiol)ÀÇ ¿¡Å׸£(ether) À¯µµÃ¼. ±¸°­ ÇÇÀÓ¾àÀ¸·Î »ç¿ëÇÑ´Ù.
ÇÁ·Î°Ô½ºÅä°Õ(progestogen) : ±×°ÍµéÀÇ ÀÓ½ÅÀüÀÇ È¿°ú¸¦ °í·ÁÇÏ¿© ¸í¸íµÈ ½ºÅ×·ÎÀ̵åµé ÁßÀÇ ÇÑ Á¾·ùÀε¥, ±×°ÍÀº ÀÓ½ÅÀ» ½ÃÀÛÇÏ°Ô ÇÏ°í Áö¼Ó½ÃÅ°´Âµ¥ ÇʼöÀûÀÌ´Ù. ÀÌ ¿©¼º È£¸£¸óµéÀº ÀÓ½ÅÀ» À§ÇÏ¿© ±×¸®°í ÀÓ½ÅÀ» Áö¼Ó½ÃÅ°±â À§ÇÏ¿© ÀÚ±ÃÀ» Áغñ½ÃŲ´Ù. ±×°ÍµéÀº ¹è¶õÀ» ¸·±â ¶§¹®¿¡, ¸¹Àº ÇÁ·ÎÁ¦½ºÆ¾ÀÌ ÇÇÀÓ¾àÀÇ ¼ººÐµé·Î¼­ »ç¿ëÇÑ´Ù. À̰͵éÀº ´ÙÀ½À» Æ÷ÇÔÇÑ´Ù.

(a) ÇÁ·Î°Ô½ºÅ×·Ð(progesterone)(INN)* : ü³»ÀÇ Á¦1±â ÇÁ·Î°Ô½ºÆ¾ÀÌ¸ç ¿¡½ºÆ®·Î°Õ¡¤¾Èµå·Î°Õ°ú ÄÚ¸£Æ¼ÄÚ½ºÅ×·ÎÀ̵å(corticosteroid)ÀÇ »ýÈ­ÇÕ °úÁ¤¿¡¼­ÀÇ Áß°£¹°. ±×°ÍÀº ³­ÀÚ ¹æÃâ ÈÄ È²»öü¿¡ ÀÇÇؼ­ »ý¼ºµÇ°í ºÎ½Å¡¤Å¹ݡ¤°íȯ¿¡¼­ »ý¼ºµÈ´Ù.

(b) ÇÁ·¹±×³­µð¿Ã(pregnandiol) : ÇÁ·Î°Ô½ºÅ׷к¸´Ù ÈξÀ ´õ ¾àÇÑ »ý¹°ÇÐÀû È°¼ºµµ¸¦ °®°í Àִ õ¿¬ÀûÀ¸·Î »ý±â´Â ÇÁ·Î°Ô½ºÆ¾ (4) ±× ¹ÛÀÇ ½ºÅ×·ÎÀ̵å È£¸£¸ó
¾Èµå·Î°Õ(androgen) : À§¿¡ Æ÷ÇÔµÇÁö ¾ÊÀº ¼ºÈ£¸£¸óÀÇ Áß¿äÇÑ ±×·ìÀ̸ç ÁÖ·Î °íȯ¿¡¼­ »ý¼ºµÇ¸ç ³­¼Ò, ºÎ½ÅÇÇÁú°ú Źݿ¡¼­ ÀûÀº ¾çÀÌ »ý¼ºµÈ´Ù. ¾Èµå·Î°ÕÀº ³²¼º ¼ºÀ» Çü¼ºÇÏ´Â ¿ªÇÒÀ» ÇÑ´Ù. ¾Èµå·Î°ÕÀº ½ÅÁø´ë»ç µî¿¡ ¿µÇâÀ» ¹ÌÄ¡¸ç µ¿È­ÀÛ¿ëÀ» ÇÑ´Ù. Å×½ºÅ佺Å×·Ð(testosterone)(INN)Àº °¡Àå Áß¿äÇÑ ¾Èµå·Î°Õµé Áß ÇϳªÀÌ´Ù.
ÀÌ ºÎºÐÀº ¶ÇÇÑ Ç׿¡½ºÆ®·Î°Õ¡¤Ç׾ȵå·Î°Õ°ú Ç×ÇÁ·Î°Ô½ºÅ×·Ð(Ç×ÇÁ·Î°Ô½ºÆ¾¡¤Ç׿¡½ºÅ¸°Õ)°ú °°Àº È£¸£¸óÀÇ ¿µÇâÀ» ¾ïÁ¦Çϰųª ¹æÇØÇϴµ¥ »ç¿ëÇÏ´Â ÇÕ¼º ½ºÅ×·ÎÀ̵åµéÀ» Æ÷ÇÔÇÑ´Ù. ½ºÅ×·ÎÀ̵å Ç×ÇÁ·Î°Ô½ºÆ¾Àº ¸î¸îÀÇ ´ç´¢º´ Ä¡·á¿¡ ¸¹ÀÌ »ç¿ëÇÏ´Â ÇÁ·Î°Ô½ºÆ¾ ±æÇ×Á¦ÀÌ´Ù. ¿¹¸¦ µé¸é, ÀÌ ±×·ì¿¡´Â ¿À³ªÇÁ¸®½ºÅæ(onapristone)(INN)°ú ¾Æ±Û·¹ÇÁ¸®½ºÅæ(aglepristone)(INN)À» Æ÷ÇÔÇÑ´Ù.
ÀÌµé ½ºÅ×·ÎÀ̵å Áß ±¹Á¦¹«¿ª»ó Áß¿äÇÑ °ÍÀº ´ÙÀ½ Ç¥¿Í °°´Ù. º» Ç¥´Â ±× ¹°Ç°ÀÇ ¾à¸íÀ» ¾ËÆĺª¼øÀ¸·Î ±âÀçÇÏ¿´°í ±× ÁÖµÈ È£¸£¸ó ÀÛ¿ëÀ» Ç¥½ÃÇÏ¿´´Ù. »ç¿ëÇÑ Ç°¸íÀº WHO¿¡¼­ °øÇ¥ÇÑ International Nonproprietary Names for pharmaceutical preparations(INN)³ª International Nonproprietary Names Modified(INNM)¿¡ ÀÇÇÏ¿´À¸¸ç, È­ÇиíÀº IUPACÀÇ 1957³â ½ºÅ×·ÎÀ̵å Ç°¸ñºÐ·ù±ÔÁ¦¿¡ ÀÇÇÑ °ÍÀÌ´Ù.


ÁַΠȣ¸£¸ó ±â´ÉÀ¸·Î »ç¿ëÇÏ´Â ½ºÅ×·ÎÀ̵åÀÇ À϶÷Ç¥
¾à¸í / È­Çиí / ÁÖÈ£¸£¸ó±â´É
Adrenosterone / androst-4-ene-3,11,17-trione / Androgen
Aldosterone (INN) / 11¥â,21-dihydroxy-3,20-dioxopregn-4-en-18-al / Corticosteroid
Allylestrenol (INN) / 17¥á-allyloestr-4-en-17¥â-ol / Progestogen
(No short name) / 5¥á-androstane-3,17-dione / Androgen intermediate
Androstanolone (INN) / 17¥â-hydroxy-5¥á-androstan-3-one / Androgen
Androstenediols / androst-5-ene-3¥â,17¥â-diol, androst-5-ene-3¥â,17¥â-diol / Anabolic intermediate
(No short name) / androst-4-ene-3,17-dione / Androgen intermediate
Androsterone / 3¥á-hydroxy-5a-androstan-17-one / Androgen
Betamethasone (INN) / 9¥á-fluoro-11¥â,17a,21-trihydroxy-16¥â-methylpregna-1,4-diene-3,20-dione / Corticosteroid
Bolasterone (INN) / 17¥â-hydroxy-7¥á,17¥á-dimethylandrost-4-en-3-one / Anabolic
Chlormadinone (INN) / 6-chloro-17¥á-hydroxypregna-4,6-diene-3,20-dione / Progestogen
Chloroprednisone (INN) / 6¥á-chloro-17¥á,21-dihydroxypregna-1,4-diene-3,11,20-trione / Corticosteroid
Clocortolone (INN) / 9¥á-chloro-6¥á-fluoro-11¥â,21-dihydroxy-16¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid
Clostebol (INN) / 4-chloro-17¥â-hydroxyandrost-4-en-3-one / Anabolic
Corticosterone / 11¥â,21-dihydroxypregn-4-ene-3,20-dione / Corticosteroid
Cortisol - see Hydrocortisone
Cortisone (INN) / 17¥á,21-dihydroxypregn-4-ene-3,11,20-trione / Corticosteroid
11-Dehydrocorticosterone / 21-hydroxypregn-4-ene-3,11,20-trione / Corticosteroid
Deoxycorticosterone - see Desoxycortone
Desoxycortone (INN) / 21-hydroxypregn-4-ene-3,20-dione / Corticosteroid
Dexamethasone (INN) / 9¥á-fluoro-11¥â,17¥á,21-trihydroxy-16¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid
Dihydroandrosterone / 5¥á-androstane-3¥á,17¥â-diol / Androgen intermediate
Dydrogesterone (INN) / 9¥â,10¥á-pregna-4,6-diene-3,20-dione / Progestogen
Equilenin / 3-hydroxyoestra-1,3,5(10),6,8-pentaen-17-one / Oestrogen
Equilin / 3-hydroxyoestra-1,3,5(10),7-tetraen-17-one /Oestrogen /
Estradiol (INN) / oestra-1,3,5(10)-triene-3,17¥â-diol / Oestrogen
Estriol (INNM) / oestra-1,3,5(10)-triene-3,16¥á,17¥â-triol / Oestrogen
Estrone (INN) / 3-hydroxyoestra-1,3,5(10)-trien-17-one / Oestrogen
Ethinylestradiol (INN) / 17¥á-ethynyloestra-1,3,5(10)-triene-3,17¥â-diol / Oestrogen
Ethisterone (INN) / 17¥á-ethynyl-17¥â-hydroxyandrost-4-en-3-one / Progestogen
Ethylestrenol (INN) / 17¥á-ethyloestr-4-en-17¥â-ol / Anabolic
Etynodiol (INN) / 17¥á-ethynyloestr-4-ene-3¥â,17¥â-diol / Progestogen
Fludrocortisone (INN) / 9¥á-fluoro-11¥â,17¥á,21-trihydroxypregn-4-ene-3,20-dione/ Corticosteroid /
Flumetasone (INN) / 6¥á,9¥á-difluoro-11¥â,17¥á,21-trihydroxy-16¥á-methylpregna-1,4-diene- 3,20-dione / Corticosteroid
Fluocinolone (INNM) / 6¥á,9¥á-difluoro-11¥â,16¥á,17¥á,21-tetrahydroxy-pregna-1,4-diene-3,20-dione / Corticosteroid
Fluocortolone (INN) / 6¥á-fluoro-11¥â,21-dihydroxy-16¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid
Fluorometholone (INN) / 9¥á-fluoro-11¥â,17¥á-dihydroxy-6¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid
9¥á-Fluoroprednisolone / 9¥á-fluoro-11¥â,17¥á,21-trihydroxypregna-1,4-diene-3,20-dione / Corticosteroid
Fluoxymesterone (INN) / 9¥á-fluoro-11¥â,17¥â-dihydroxy-17¥á-methylandrost-4-en-3-one / Androgen
Fluprednidene (INN) / 9¥á-fluoro-11¥â,17¥á,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione / Corticosteroid
Fluprednisolone (INN) / 6¥á-fluoro-11¥â,17¥á,21-trihydroxypregna-1,4-diene-3,20-dione / Corticosteroid
Flurandrenolone / 6¥á-fluoro-11¥â,16¥á,17¥á,21-tetrahydroxypregn-4-ene-3,20-dione / Corticosteroid
Formocortal (INN) / 3-(2-chloroethoxy)-9¥á-fluoro-6-formyl-11¥â,21-dihydroxy-16¥á,17-isopropylidenedioxypregna-3,5-dien-20 one 21-acetate / Corticosteroid
Gestonorone (INNM) / 17¥â-ethyl-17¥á-hydroxyoestr-4-ene-3,20-dione / Progestogen
Hydrocortisone (INN) / 11¥â,17¥á,21-trihydroxypregn-4-ene-3,20-dione / Corticosteroid
Hydroxyprogesterone (INN) / 17¥á-hydroxypregn-4-ene-3,20-dione / Progestogen
Lynestrenol (INN) / 17¥á-ethynyloestr-4-en-17¥â-ol / Progestogen
Medroxyprogesterone (INN) / 17¥á-hydroxy-6¥á-methylpregn-4-ene-3,20-dione / Progestogen
Megestrol (INN) / 17¥á-hydroxy-6-methylpregna-4,6-diene-3,20-dione / Progestogen
Mestanolone (INN) / 17¥â-hydroxy-17¥á-methyl-5¥á-androstan-3-one / Anabolic
Mesterolone (INN) / 17¥â-hydroxy-1¥á-methyl-5¥á-androstan-3-one / Androgen
Mestranol (INN) / 17¥á-ethynyl-3-methoxyoestra-1,3,5(10)-trien-17¥â-ol / Oestrogen
Metandienone (INN) / 17¥â-hydroxy-17¥á-methylandrosta-1,4-dien-3-one / Anabolic
Metenolone (INN) / 17¥â-hydroxy-1-methyl-5¥á-androst-1-en-3-one / Anabolic
Methandriol (INN) / 17¥á-methylandrost-5-ene-3¥â,17¥â-diol / Anabolic
2-Methylhydrocortisone / 11¥â,17¥á,21-trihydroxy-2¥â-methylpregn-4-ene-3,20-dione / Corticosteroid
6¥á-Methylhydrocortisone / 11¥â,17¥á,21-trihydroxy-6¥á-methylpregn-4-ene-3,20-dione / Corticosteroid
Methylnortestosterone / 17¥â-hydroxy-17¥á-methyloestr-4-en-3-one / Progestogen
17¥á-Methyloestradiol / 17¥á-methyloestra-1,3,5(10)-triene-3,17¥â-diol / Oestrogen
Methylprednisolone (INN) / 11¥â,17¥á,21-trihydroxy-6¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid
Methyltestosterone (INN) / 17¥â-hydroxy-17¥á-methylandrost-4-en-3-one / Androgen
Nandrolone (INN) / 17¥â-hydroxyoestr-4-en-3-one / Anabolic
Norethandrolone (INN) / 17¥á-ethyl-17¥â-hydroxyoestr-4-en-3-one / Anabolic
Norethisterone (INN) / 17¥á-ethynyl-17¥â-hydroxyoestr-4-en-3-one / Progestogen
Noretynodrel (INN) / 17¥á-ethynyl-17¥â-hydroxyoestr-5(10)-en-3-one / Progestogen
Norgestrel (INN) / 13¥â-ethyl-17¥á-ethynyl-17¥â-hydroxygon-4-en-3-one / Progestogen
Normethandrone - see Methylnortestosterone
Nortestosterone - see Nandrolone
Oxabolone (INNM) / 4,17¥â-dihydroxyoestr-4-en-3-one / Anabolic
Oxymesterone (INN) / 4,17¥â-dihydroxy-17¥á-methylandrost-4-en-3-one / Anabolic
Oxymetholone (INN) / 17¥â-hydroxy-2-hydroxymethylene-17¥á-methyl-5¥á-androstan-3-one / Anabolic
Paramethasone (INN) / 6¥á-fluoro-11¥â,17¥á,21-trihydroxy-16¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid
Prasterone (INN) / 3¥â-hydroxyandrost-5-en-17-one / Androgen
Prednisolone (INN) / 11¥â,17¥á,21-trihydroxypregna-1,4-diene-3,20-dione / Corticosteroid
Prednisone (INN) / 17¥á,21-dihydroxypregna-1,4-diene-3,11,20-trione / Corticosteroid
Prednylidene (INN) / 11¥â,17¥á,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione / Corticosteroid
Pregnenolone (INN) / 3¥â-hydroxypregn-5-en-20-one / Corticosteroid
Progesterone (INN) / pregn-4-ene-3,20-dione / Progestogen
Stanolone - see Androstanolone
Testosterone (INN) / 17¥â-hydroxyandrost-4-en-3-one / Androgen
Tiomesterone (INN) / 1¥á,7¥á-di(acetylthio)-17¥â-hydroxy-17¥á-methylandrost-4-en-3-one / Anabolic
Triamcinolone (INN) / 9¥á-fluoro-11¥â,16¥á,17¥á,21-tetrahydroxypregna-1,4-diene-3,20-dione / Corticosteroid

(C) ÇÁ·Î½ºÅ¸±Û¶õµò(prostaglandin), Æ®·Òº¹»ê(thromboxane) ±×¸®°í ·ùÄÚÆ®¸®¿£(leukotriene)¡¤±× À¯µµÃ¼¿Í ±¸Á¶Àû À¯»çü
ÀÌ »ý¼º¹°µéÀº ¾Æ¶óÅ°µ·»ê(arachidonic acid)ÀÇ À¯µµÃ¼´Ù.

(1) ÇÁ·Î½ºÅ¸±Û¶õµò(prostaglandin)
°¡Àå Áß¿äÇÑ ¾Æ¶óÅ°µ·»ê(arachidonic acid) À¯µµÃ¼´Â È£¸£¸óÀ¸·Î¼­ ¹Ì¼Ò·®¿¡¼­µµ ÀÛ¿ëÇÏ´Â ±×¸®°í ÇÁ·Î½ºÅ¸³ë»êÀÇ ±âº»ÀûÀÎ ±¸Á¶¸¦ Æ÷ÇÔÇÏ´Â ³»»ýÀû ¹°ÁúÀÎ ÇÁ·Î½ºÅ¸±Û¶õµò(prostaglandin)ÀÌ´Ù. ÇÁ·Î½ºÅ¸±Û¶õµòÀº Ç÷¾× ¼øȯ¡¤ÄáÆÏ ±â´É ±×¸®°í ¿£µå·ÎÅ©¸°(endrocrine) ü°è[¿¹¸¦ µé¸é Ȳü(üÜô÷)¿¡ ÀÇÇÑ ÇÁ·Î°Ô½ºÅ×·ÐÀÇ »ý¼ºÀ» ÁÙÀÓÀ¸·Î½á]ÀÇ Á¶Àý¿¡ ¿µÇâÀ» ³¢Ä¡¸ç; À̰͵éÀº ¶ÇÇÑ À¯¿¬ÇÑ ±ÙÀ°ÀÇ ¼öÃà ȤÀº Ç÷°üÀÇ È®ÀåÀ» ÀÚ±ØÇÏ°í Ç÷¼ÒÆÇ ÀÀÁýÀ» ¸·À¸¸ç À§¼±ºÐºñ¸¦ Á¶ÀýÇÑ´Ù. À̰͵éÀº ¾Æ·¡ÀÇ ÇÁ·Î½ºÅ¸±Û¶õµò¡¤À¯µµÃ¼ ±×¸®°í ±¸Á¶Àû À¯»çü¸¦ Æ÷ÇÔÇÑ´Ù.

(a) ¾ËÇÁ·Î½ºÅ¸µô(alprostadil)(INN)(ÇÁ·Î½ºÅ¸±Û¶õµò E1) : »ý¹°ÇÐÀû ÃßÃâ¹°(extract) µî¿¡¼­ °áÁ¤È­µÈ 1±â ÇÁ·Î½ºÅ¸±Û¶õµòÀÌ´Ù. ÀÌ°ÍÀº Ç÷°üÈ®ÀåÁ¦·Î »ç¿ëÇÑ´Ù. ÀÌ°ÍÀº ¶ÇÇÑ ÄáÆÏ ²®Áú¿¡¼­ ¿¡¸®Æ®·ÎÆ÷¿¡Æ¾ÀÇ ¹æÃâÀ» ÀÚ±ØÇÏ´Â ±â´ÉÀ» ÇÏ°í Ç÷¾× Ç÷¼ÒÆÇ ÀÀÁýÀ» ¾ïÁ¦ÇÑ´Ù.

(b) ¾ËÆÄÇÁ·Î½ºÅç(alfaprostol)(INN) : ´ç³ª±Í¡¤³ë»õ µîÀÇ ¾ÏÄƵéÀÇ ºÒÀÓÁõ Ä¡·á¿¡ »ç¿ëÇÏ´Â ÇÕ¼º ÇÁ·Î½ºÅ¸±Û¶õµò À¯»çü

(c) Æ¿¼öÇÁ·Î½ºÆ®(tilsuprost)(INN) :´ÝÈù °í¸®±¸Á¶¸¦ °¡Áö¸ç »ê¼Ò¿Í ź¼Ò ¿øÀÚ°¡ Áú¼Ò¿Í Ȳ ¿øÀÚ·Î ´ëüµÈ ÇÁ·Î½ºÅ¸±Û¶õµò À¯»çü. ÇÕ¼º ÇÁ·Î½ºÅ¸±Û¶õµòÀ̸ç ÇÁ·Î½ºÅ¸±Û¶õµò ¼ö¿ëü ÀÛ¿ëÁ¦ÀÌ´Ù.
ÀÌ ±×·ìÀº ÇÁ·Î½ºÅ»·»(prostalene)(INN)¡¤µð³ëÇÁ·Î½ºÆ®(dinoprost)(INN) °°Àº ´Ù¸¥ ÇÕ¼º »ý¼º¹°µéµµ Æ÷ÇÔÇϴµ¥, ±×°ÍÀº ÀÚ¿¬ÀûÀÎ »ý¼º¹°µéÀÇ ±âº»ÀûÀÎ ±¸Á¶¸¦ º¸À¯ÇÏ°í ºñ½ÁÇÑ »ý¸®ÇÐÀû È°¼ºµµ¸¦ °¡Áö°í ÀÖ´Ù.

(2) Æ®·Òº¹»ê(thromboxane)°ú ·ùÄÚÆ®¸®¿£(leukotriene)
Æ®·Òº¹»ê°ú ·ùÄÚÆ®¸®¿£Àº ÇÁ·Î½ºÅ¸±Û¶õµòó·³ ¾Æ¶óÅ°µ·»ê¿¡ ÀÇÇØ ¼¼Æ÷ ³»¿¡¼­ ÇÕ¼ºµÇ¸ç; À̵éÀÇ ±â´ÉÀº ÇÁ·Î½ºÅ¸±Û¶õµò(prostaglandin)°ú ºñ½ÁÇÏ°í À̵éÀÇ ±¸Á¶µµ ¸Å¿ì ºñ½ÁÇÏÁö¸¸, ÇÁ·Î½ºÅº »êÀÇ ±âº»ÀûÀÎ ±¸Á¶¸¦ Æ÷ÇÔÇÏÁö ¾Ê´Â´Ù. Æ®·Òº¹»êÀº »ýÇÕ¼ºÀûÀ¸·Î ÇÁ·Î½ºÅ¸±Û¶õµò¿¡¼­ À¯µµµÈ´Ù. À̵éÀº Ç÷¼ÒÆÇ ÀÀÁý°ú µ¿¸ÆÀÇ ¼öÃàÀ» ¾ß±âÇÏ°í ´ÙºÒÆ÷È­ Áö¹æ»ê ÀÛ¿ëÀÇ Áß¿äÇÑ Á¶Àý ÀÎÀÚÀÌ´Ù. ·ùÄÚÆ®¸®¿£Àº ¹éÇ÷±¸ ³»¿¡¼­ÀÇ »ý¼º°ú À̵éÀÇ º¹ÇÕÀûÀÎ Æ®¸®¿£ ±¸Á¶·Î ÀÎÇØ ±×·¸°Ô ¸í¸íµÇ¾ú´Ù. À̵éÀº È¿´ÉÀÌ ÀÖ´Â ±â°üÁö ¼öÃàÁ¦ÀÌ°í °ú¹Î¼º ¹ÝÀÀ¿¡¼­ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù.

(a) Æ®·Òº¹»ê B2 : Ç÷°ü¼öÃàÁ¦¡¤±â°üÁö¼öÃàÁ¦¿Í Ç÷¾× Ç÷¼ÒÆÇ ÀÀÁýÀÇ À¯¹ßÀÎÀÚ

(b) ·ùÄÚÆ®¸®¿£ C4 : È÷½ºÅ¸¹ÎÀ̳ª ÇÁ·Î½ºÅ¸±Û¶õµòÀÌ ÆóÀÇ ±âµµ(ѨԳ)¿¡ ÀÛ¿ëÇÏ´Â È¿°úº¸´Ù 100¹è¿¡¼­ 1,000¹è ´õ È¿·ÂÀÌ ÀÖ´Â °ÍÀ¸·Î ¹àÇôÁ³´Ù.

(D) ´Ù¸¥ È£¸£¸óµé
¿©±â¿¡ ºÐ·ùÇÑ °ÍµéÀº ±× ±¸Á¶°¡ À§¿¡ ¾ð±ÞµÈ È£¸£¸óµéÀÇ ±¸Á¶¿Í´Â ´Ù¸¥ ±× ¹ÛÀÇ È£¸£¸óµéÀÌ´Ù. ÇÑ ¿¹·Î ¸á¶óÅä´Ñ(melatonin)ÀÌ Àִµ¥, ±×°ÍÀº ¼Û°ú¼±(áæÍýàÍ : pineal gland)¿¡¼­ ¹ß°ßµÇ°í Àε¹ÀÇ À¯µµÃ¼·Î °£ÁÖµÉ ¼ö ÀÖ´Ù. ¿©±â¿¡ ºÐ·ùÇÏ´Â ±× ¹ÛÀÇ È£¸£¸óµéÀº ´ÙÀ½°ú °°´Ù.

(1) Ä«Å×Äݶó¹Î(catecholamine) È£¸£¸óµé, ±× À¯µµÃ¼¿Í ±¸Á¶ÀûÀÎ À¯»çü
ÀÌ È£¸£¸ó ±×·ìÀº ºÎ½Å(adrenal gland)ÀÇ ¼öÁúÃþ¿¡¼­ ¹ß°ßµÇ´Â °ÍµéÀ» Æ÷ÇÔÇÑ´Ù.

(a) ¿¡Çdz×ÇÁ¸°(epinephrine)(INN)(¾Æµå·¹³¯¸°À̳ª (-)-3,4-µðÈ÷·Ï½Ã-¥á-[(¸ÞÆ¿¾Æ¹Ì³ë)¸ÞÆ¿]º¥Áú ¾ËÄÚ¿Ã)°ú ·¹½ÃÇÉÇÁ¸°(racepinephrine)(INN)((¡¾)-3,4-µðÈ÷·Ï½Ã-¥á-[(¸ÞÆ¿¾Æ¹Ì³ë)¸ÞÆ¿]º¥Áú ¾ËÄÚ¿Ã) : ÀÌ µÎ È£¸£¸óµéÀÇ ±¸Á¶´Â È­ÇÐÀûÀÎ À̸§ 1-(3,4-µðÈ÷·Ï½ÃÆä´Ò)-2-¸ÞÆ¿¾Æ¹Ì³ë¿¡Åº¿Ã°ú ÀÏÄ¡ÇÑ´Ù. ¿¡Çdz×ÇÁ¸°Àº ºû¿¡ ÀÇÇؼ­ ¿µÇâÀ» ¹Þ´Â ¹àÀº °¥»öÀ̳ª °ÅÀÇ Èò»öÀÇ °áÁ¤¼º °¡·çÀÌ´Ù. ±×°ÍÀº ¹°°ú À¯±â ¿ëÁ¦(éÁð¥ : solvent)¿¡¼­ Á¶±Ý ³ì´Â´Ù. ±×°ÍÀº ¸»ÀÇ ºÎ½Å¿¡¼­ À¯µµµÉ ¼ö ÀÖÀ¸³ª ÇÕ¼º¿¡ ÀÇÇؼ­ ÁÖ·Î ¾ò¾îÁø´Ù. °íÇ÷¾Ð È£¸£¸óÀÌ Àִµ¥, ÀÌ°ÍÀº ±³°¨½Å°æ°è¸¦ ÀÚ±ØÇÏ°í Ç÷±¸(corpuscle)ÀÇ ¼ö¿Í Ç÷¾×¼Ó¿¡ ´çÀÇ ÇÔ·®À» Áõ°¡½ÃŲ´Ù. ÀÌ°ÍÀº °­ÇÑ Ç÷°ü ¼öÃà ÀÛ¿ëÀ» ÇÑ´Ù.

(b) ³ë¸£¿¡Çdz×ÇÁ¸°(norepinephrine)(INN)[·¹¹ÙÅ×·¹³î, ³ë¸£¾Æµå·¹³¯¸° ¶Ç´Â (-)-2-¾Æ¹Ì³ë-1-(3,4-µðÈ÷µå·Ï½ÃÆä´Ò)¿¡Åº¿Ã] : ³ë¸£¿¡Çdz×ÇÁ¸°Àº ¹°¿¡¼­ ³ì´Â Èò °áÁ¤Ã¼·Î ³ªÅ¸³­´Ù. ÀÌ°ÍÀÇ »ý¸®ÇÐÀû È°¼ºµµ´Â ¾Æµå·¹³¯¸°°ú ¿¡Æäµå¸° »çÀÌÀÇ Áß°£ÀÌ´Ù.

(2) ¾Æ¹Ì³ë»ê À¯µµÃ¼

(a) ·¹º¸Å¸À̷ϽÅ(levothyroxine)(INNM)°ú DL-ŸÀ̷ϽÅ(3-[4-(4-È÷µå·Ï½Ã-3,5-µð¿ÀµµÆä³ì½Ã(diiodophenoxy))-3,5-µð¾ÆÀÌ¿ÀµµÆä´Ò(diiodophenyl)]¾Ë¶ó´ÑÀ̳ª 3,5,3',5'-Å×Æ®¶ó¾ÆÀÌ¿ÀµµÆ¼·Î´Ñ(tetraiodothyronine) : ŸÀ̷ϽÅÀº °©»ó¼±¿¡¼­ ÃßÃâµÇ°Å³ª ÇÕ¼º¿¡ ÀÇÇؼ­ ¾ò¾îÁø´Ù. ÀÌ°ÍÀº ¹æÇ⼺(Û»úÅàõ) ¾Æ¹Ì³ë»êÀ̸ç; ¹°À̳ª ¾î¶°ÇÑ ÀϹÝÀûÀÎ ¿ëÁ¦(éÁð¥ : solvent)¿¡¼­µµ ³ìÁö ¾Ê´Â Èò»öÀ̳ª ´©¸£½º¸§ÇÑ °áÁ¤Ã¼µé·Î ³ªÅ¸³­´Ù. ÀÌ°ÍÀº ±âÃÊ ´ë»çÀ²°ú »ê¼Ò ¼Ò¸ð¸¦ Áõ°¡½ÃÅ°°í ±³°¨ ½Å°æ°è¸¦ ¿òÁ÷ÀÌ°í ´Ü¹éÁú°ú Áö¹æÀÇ ÀÛ¿ëÀ» Á¶ÀýÇϸç À¯±âüÀÇ ¸ðµç ¿ä¿Àµå °áÇÌÀ» º¸ÃæÇÏ¸ç °©»ó¼±Á¾°ú Å©·¹Æ¾ º´À» Ä¡·áÇϱâ À§ÇÏ¿© »ç¿ëÇÑ´Ù. L-À̼ºÃ¼´Â È°¼ºÃ¼ÀÌ´Ù. ³ªÆ®·ý ½Ä¿°Àº À¯»çÇÑ È°¼ºµµ¸¦ °®°í ¹°¿¡ Á¶±Ý ³ì´Â Èò °¡·çÀÌ´Ù.

(b) ¸®¿ÀŸÀ̷δÑ(liothyronine)(INN)°ú ·¡Å¸À̷δÑ(rathyronine)(INN) (DL-3,5,3'-Æ®¸®¿ä¿ÀµåŸÀ̷δÑ)(3-[4-(4-È÷µå·Ï½Ã-3ÀÌ¿ÀµµÆä³ì½Ã-3,5-´ÙÀ̾ÆÀÌ¿ÀµµÆä´Ò]¾Ë¶ó´Ñ)(DL-3,5,3'-triiodothyronine)(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine) : Æ®¸®¾ÆÀÌ¿ÀµåŸÀ̷δÑÀº °©»ó¼±¿¡¼­µµ ÃßÃâµÇ¸ç; ÀÌ°ÍÀÇ »ý¸®ÇлóÀÇ È°¼ºµµ´Â ŸÀ̷Ͻź¸´Ùµµ ´õ Å©´Ù.


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