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(3) ºÎ½ÅÇÇÁúÀÚ±ØÈ£¸£¸ó(corticotropin)(INN)[¾Æµå·¹³ëÄÚ¸£Æ¼ÄÚÆ®·ÎÇÈ È£¸£¸ó(ACTH : adreno corticotropic hormone)¡¤¾Æµå·¹³ëÄÚ¸£Æ¼ÄÚÆ®·ÎÇÉ] : ¹°¿¡ ³ì´Â Æú¸® ÆéŸÀ̵å·Î¼ ¾Æµå·¹³ëÄÚ¸£Æ¼Ä® ½ºÅ×·ÎÀ̵åÀÇ »ý¼ºÀ» ÀÚ±ØÇÑ´Ù. Áö·¢Æ¼µå(Giractide)(INN)µµ ºÎ½ÅÇÇÁúÀÚ±ØÈ£¸£¸óÀÇ À¯»ç¹°ÁúÀÌ´Ù. (4) À¯ÁóºÐºñÈ£¸£¸ó(lactogenic hormone : LTH¡¤°¥¶ôƾ¡¤°¥¶ôÅäÁø È£¸£¸ó¡¤·çÅ׿ÀÆ®·ÎÇÉ¡¤¸¶¸ðÆ®·ÎÇÉ¡¤ÇÁ·Î¶ôƾ) : °áÁ¤¼ºÀÇ Æú¸®ÆéŸÀ̵å(polypeptide)·Î¼ À¯ÁóºÐºñ(êáñðÝÂÝô : milk secretion)ÀÛ¿ëÀ» ÃËÁøÇÏ°í Ç×ü(corpus luteum)ÀÇ È°¼º¿¡ ¿µÇâÀ» ÁØ´Ù. (5) °©»ó¼±ÀÚ±ØÈ£¸£¸ó(thyrotrophin)(INN)(Ƽ·ÎÆ®·ÎÇÈ È£¸£¸ó¡¤TSH : thyroid-stimulating hormone) : Ç÷¾× ÁßÀÇ °©»ó¼± ÀÛ¿ë°ú ¿ä¿ÀµåÀÇ À̵¿¿¡ °ÔÀçÇÏ´Â ´ç´Ü¹éÁú(glycoprotein)ÀÌ´Ù. ¼ºÀå°ú ºÐºñ¿¡ ¿µÇâÀ» ¹ÌÄ£´Ù. (6) ³Æ÷ÀÚ±ØÈ£¸£¸ó(follicle-stimulating hormone : FSH) : ´ç´Ü¹éÁúÀ¸·Î¼ ¹°¿¡ ³ìÀ¸¸ç ¼º±â´ÉÀ» ÀڱؽÃŲ´Ù. (7) ȲüÇü¼ºÈ£¸£¸ó[luteinising hormone : LH¡¤(Á¶Á÷ »çÀÌÀÇ ¼¼Æ÷ÀÚ±Ø È£¸£¸ó)(ICSH : interstitial-cell-stimulating hormone), ·çÅ×À̳뽺Ƽ¹Ä¸°] : ¼ö¿ë¼º±Û¸®ÄÚÇÁ·ÎÅ×ÀΡ¤½ºÅ×·ÎÀÌµå ºÐºñ¿Í ¹è¶õ°ú Á¶Á÷ »çÀÌÀÇ ¼¼Æ÷Çü¼ºÀ» ÃËÁøÇÏ¸é¼ ¼º±â´ÉÀ» ÀÚ±ØÇÑ´Ù. (8) À¶¸ð¸·(chorionic) °í³ªµµÆ®·ÎÇÉ(INN)(hCG : »ç¶÷ À¶¸ð¼º ¼º¼± ÀÚ±ØÈ£¸£¸ó) : ÅÂ¹Ý Áß¿¡¼ »ý¼ºµÇ´Â ´ç´Ü¹éÁú(glycoprotein)À¸·Î¼ ÀÓ»êºÎÀÇ ¼Òº¯¿¡¼ ÃßÃâµÈ´Ù. ¹é»ö °áÁ¤Ã¼·Î¼ ±× ¼ö¿ë¾×Àº ºÒ¾ÈÁ¤ÇÏ¸ç ³Æ÷ÀÇ ¼º¼÷À» ÀڱؽÃŲ´Ù. (9) Ç÷û°í³ªµµÆ®·ÎÇÉ(INN)(eCG : ¸»ÀÇ À¶¸ð¼º ¼º¼± ÀÚ±Ø È£¸£¸ó) : »ý½Ä¼± ÀÚ±ØÀÛ¿ëÀ» ÇÏ´Â ´ç´Ü¹éÁú(glycoprotein)À¸·Î¼ ÀÓ½ÅÇÑ ¸»ÀÇ Å¹ݰú Àڱ󻸷¿¡¼ »ý¼ºµÈ´Ù. º»·¡ ÀÓ½ÅÇÑ ¸»ÀÇ Ç÷û°í³ªµµÆ®·ÎÇÉÀ¸·Î ºÒ¸°´Ù. (10) ¿Á½ÃÅä½Å(oxytocin)(INN)[¾ËÆÄ(¥á)-È÷Æ÷ÆĹÎ] : Æú¸®ÆéŸÀ̵å(polypeptide)·Î¼ ¹°¿¡ ³ìÀ¸¸ç ÁÖ·Î Àڱà ¼öÃà°ú À¯¼±ÀÇ À¯ºÐÃâ ÀÛ¿ëÀ» ÇÑ´Ù. ¶ÇÇÑ Ä«¸£º£Åä½Å(carbetocin)(INN)¡¤µ¥¸ñ½ÃÅä½Å(demoxytocin)(INN) µîÀÇ À¯»ç ¹°Áúµµ Æ÷ÇÔÇÑ´Ù. (11) Ç÷°ü¼öÃàÈ£¸£¸ó(vasopressin) : ¾Æ¸£±âÇÁ·¹½Å(INN)°ú ¸®ÇÁ·¹½Å(INN)¡¤±× À¯µµÃ¼¿Í À¯»çÇÑ ±¸Á¶¸¦ °¡Áø ¹°Áú¡¤Ç÷°ü¼öÃàÈ£¸£¸óÀº Æú¸®ÆéŸÀ̵å(polypeptide)·Î¼ Ç÷¾Ð»ó½ÂÀÛ¿ë°ú ÄáÆÏÀÇ º¸¼ö·Â Áõ°¡ÀÛ¿ëÀ» ÇÑ´Ù. ¶ÇÇÑ Å׸£¸®ÇÁ·¹½Å(terlipressin)(INN)¡¤µ¥½º¸ðÇÁ·¹½Å(desmopressin)(INN)°ú °°Àº Æú¸®ÆéŸÀ̵å(polypeptide) À¯»ç¹°Áúµµ Æ÷ÇÔÇÑ´Ù. (12) Ä®½ÃÅä´Ñ(calcitonin)(INN)(TCA : Ƽ·ÎÄ®½ÃÅä´Ñ) : Æú¸®ÆéŸÀ̵å(polypeptide)·Î¼ Ç÷¾× Áß Æ÷µµ´çÀÇ ³óµµ¸¦ Áõ°¡½ÃÅ°´Â Ư¼ºÀÌ ÀÖ´Ù. (13) ±Û·çÄ«°ï(glucagon)(INN)(HGF : ÇÏÀÌÆÛ±Û¸®¼¼¹Í-±Û¸®ÄڰԳ븮ƽ ÀÎÀÚ) : Æú¸®ÆéŸÀ̵å·Î¼ Ç÷¾× Áß Æ÷µµ´çÀÇ ³óµµ¸¦ Áõ°¡½ÃÅ°´Â Ư¼ºÀÌ ÀÖ´Ù. (14) Ƽ·Ñ¸®º£¸°(thyroliberin)(TRF¡¤TRH) : Æú¸®ÆéŸÀ̵å·Î¼ Ƽ·ÎÆ®·ÎÇÉ(thyrotropin)ÀÇ ºÐºñ¸¦ ÀڱؽÃŲ´Ù. (15) °í³ªµµ·¼¸°(gonadorelin)(INN)(°í³ªµµ¸±º£¸°¡¤°í³ªµµÆ®·ÎÇÉ ÀÚ±ØÈ£¸£¸ó¡¤LRF¡¤GnRH) : Æú¸®ÆéŸÀ̵å·Î¼ ³úÇϼö¼±¿¡¼ ³Æ÷¿Í Ȳü ÀÚ±Ø È£¸£¸óÀÇ ºÐºñ¸¦ ÃËÁø½ÃŲ´Ù. ¶ÇÇÑ Æú¸®ÆéŸÀ̵å À¯»ç¹°Áú ºÎ¼¼¸±¸°(buserilin)(INN)¡¤°í¼¼¸±¸°(goserilin)(INN)¡¤Æ丣Ƽ·¼¸°(fertirelin) (INN) ¡¤¼¼¸£¸ð·¼¸°(sermorelin)(INN) µîµµ Æ÷ÇÔÇÑ´Ù. (16) ¼Ò¸¶Å佺Ÿƾ(somatostatin)(INN)(SS¡¤SRIH¡¤SRIF) : Æú¸®ÆéŸÀ̵å·Î¼ ³úÇϼö¼±À¸·ÎºÎÅÍ ¼ºÀåÈ£¸£¸ó°ú TSHÀÇ ¹æÃâÀ» ¾ïÁ¦ÇÏ¸ç ½Å°æÄ£ÈÀÛ¿ëÀ» ÇÑ´Ù. (17) ½É¹æ¼º ³ªÆ®·ýÀÌ´¢ È£¸£¸ó(atrial natriuretic hormone : ANH¡¤ANF) : ½ÉÀåÀÇ ½É¹æ¿¡¼ºÎÅÍ ºÐºñµÇ´Â Æú¸®ÆéƼµå È£¸£¸óÀÌ´Ù. Ç÷¾×ÀÇ ºÎÇÇ°¡ Áõ°¡ÇÏ¿© ½ÉÀåÀÇ ½É¹æÀÌ È®ÀåµÉ ¶§ ANH°¡ ºÐºñµÇµµ·Ï ÀڱصȴÙ. ±× ´ÙÀ½ ANH´Â ¼Ò±Ý°ú ¹°ÀÇ ¹è¼³À» Áõ°¡½ÃÅ°°í Ç÷¾ÐÀ» °¨¼Ò½ÃŲ´Ù. (18) ¿£µµÅÚ¸°(endothelin) : ¸Æ°ü ±¸Á¶ Àüü¿¡ ÆÛÁ® ÀÖ´Â ³»ÇǼ¼Æ÷¿¡¼ ºÐºñµÇ´Â Æú¸®ÆéƼµå È£¸£¸óÀÌ´Ù. ¿£µµÅÚ¸°ÀÌ ¼øȯµÇ´Â Ç÷¾×À¸·Î ¹æÃâµÈ´Ù ÇÒÁö¶óµµ, ±×°ÍÀº ÃøºÐºñ(ö°ÝÂù² : paracrine) °æÇâ¿¡ ÀÇÇØ ÀÎÁ¢ÇÑ Ç÷°üÀÇ ÆòÈ°±ÙÀ» ¼öÃàÇϵµ·Ï ±×¸®°í Ç÷¾ÐÀ» Áõ°¡ ½ÃÅ°µµ·Ï ±¹ºÎÀûÀ¸·Î È°µ¿ÇÑ´Ù. (19) ÀÎÈ÷ºó(inhibin)°ú ¾×Ƽºó(activin) : »ý½Ä¼±(gonadal) Á¶Á÷¿¡¼ ¹ß°ßµÇ´Â È£¸£¸óÀÌ´Ù. (20) ·¾Æ¾(leptin) : Æú¸®ÆéŸÀ̵å È£¸£¸óÀ¸·Î¼ ³úÀÇ ¼ö¿ëü¿¡¼ ½Åü Áß·®°ú Áö¹æ ħÂøÀ» Á¶ÀýÇÏ´Â ¿ªÇÒÀ» ÇÏ´Â °ÍÀ¸·Î ¹Ï¾îÁö´Â Áö¹æ Á¶Á÷¿¡ ÀÇÇØ »ý»êµÈ´Ù. ¶ÇÇÑ ¿©±â¿¡´Â ·¾Æ¾ÀÇ ÀçÁ¶ÇÕ ¸ÞƼ¿À´Ò À¯µµÃ¼ÀÎ ¸ÞÆ®·¹·¾Æ¾(metreleptin)(INN)ÀÌ Æ÷ÇԵǴµ¥, ÀÌ´Â ·¾Æ¾ÀÇ À¯»çü·Î °£ÁÖÇÏ¸ç ·¾Æ¾°ú À¯»çÇÑ È°µ¿À» ÇÑ´Ù. (B) ½ºÅ×·ÎÀ̵å È£¸£¸ó¡¤±× À¯µµÃ¼¿Í ±¸Á¶Àû À¯»çü (1) ÄÚ¸£Æ¼ÄÚ½ºÅ×·ÎÀ̵å(corticosteroid) È£¸£¸ó : ºÎ½ÅÇÇÁúÀÇ ¿ÜÇÇ¿¡¼ ºÐºñµÇ¾î ÀÎüÀÇ ½ÅÁø´ë»ç¸¦ À§ÇØ Áß¿äÇÑ ¿ªÇÒÀ» ÇÑ´Ù. ±×°ÍµéÀº ºÎ½ÅÇÇÁú È£¸£¸ó°ú ÄÚ¸£Æ¼ÄÚÀ̵å¶ó°í ¾Ë·ÁÁ® ÀÖÀ¸¸ç ÀϹÝÀûÀ¸·Î ±×µéÀÇ »ý¸®Àû ÀÛ¿ë¿¡ µû¶ó µÎ ±×·ìÀ¸·Î ³ªÀ§¾îÁø´Ù. Áï (¥¡) ´Ü¹éÁú°ú ź¼öȹ°ÀÇ ´ë»ç ÀÛ¿ëÀ» Á¶ÀýÇÏ´Â ´çÁú ºÎ½ÅÇÇÁú È£¸£¸ó°ú (¥¢) ÀÎüÀÇ ³ªÆ®·ý°ú ¹°À» À¯ÁöÇÏ°í Ä®·ýÀÇ ¹è¼³ ÃËÁøÇÏ´Â ÀüÇØÁú ºÎ½ÅÇÇÁú È£¸£¸óÀÌ ÀÖ´Ù. ÀüÇØÁú ºÎ½ÅÇÇÁú È£¸£¸óÀÇ Æ¯Â¡Àº ¿¡µð½¼º´À̳ª ÄáÆÏ °áÇÌÀÇ Ä¡·á¿¡ ÀÌ¿ëµÈ´Ù. À̵éÀº ¾Æ·¡ÀÇ ÄÚ¸£Æ¼ÄÚ½ºÅ×·ÎÀ̵å È£¸£¸ó¡¤À¯µµÃ¼¿Í À¯»çüµéÀ» Æ÷ÇÔÇÑ´Ù. (a) ÄÚ¸£Æ¼¼Õ(cortisone)(INN)*: ´Ü¹éÁú°ú ź¼öȹ° ´ë»ç ÀÛ¿ëÀ» Á¶ÀýÇÏ°í ¶ÇÇÑ ±¹ºÎÀûÀÎ ¼Ò¿°ÀÛ¿ëÀ» ÇÏ´Â ´çÁú ºÎ½ÅÇÇÁú È£¸£¸ó (b) È÷µå·ÎÄÚ¸£Æ¼¼Õ(hydrocortisone)(INN)(ÄÚ¸£Æ¼Á¹)* : ÄÚ¸£Æ¼¼Õ°ú À¯»çÇÑ ÀÛ¿ëÀ» ÇÏ´Â ´çÁú ºÎ½ÅÇÇÁú È£¸£¸ó (c) ÇÁ·¹µå´Ï¼Õ(prednisone)(INN)(Å»È÷µå·ÎÄÚ¸£Æ¼¼Õ) : ´çÁú ºÎ½ÅÇÇÁú È£¸£¸ó¡¤ÄÚ¸£Æ¼¼ÕÀÇ À¯µµÃ¼ (d) ÇÁ·¹µå´Ï¼Ö·Ð(prednisolone)(INN)(Å»È÷µå·ÎÈ÷µå·ÎÄÚ¸£Æ¼¼Õ) : ´çÁú ¼ö½ÅÇÇÁú È£¸£¸ó¡¤È÷µå·ÎÄÚ¸£Æ¼¼ÕÀÇ À¯µµÃ¼ (e) ¾Ëµµ½ºÅ×·Ð(aldosterone)(INN) : ÀüÇØÁú ºÎ½ÅÇÇÁú È£¸£¸ó (f) ÄÚ¸£Å䵶¼Õ(cortodoxone)(INN) ¸î¸î À¯µµÃ¼´Â À̵éÀÇ Ç׿° ÀÛ¿ë¿¡ µµ¿òÀÌ µÇµµ·Ï À̵éÀÇ ÇÇÁö È£¸£¸ó ¿µÇâÀ» ¾ïÁ¦½ÃÅ°±â À§ÇØ º¯ÇüµÇ¸ç ±×°ÍÀº È£¸£¸ó ÀÛ¿ëÀ¸·Î °£ÁÖµÉ °ÍÀÌ´Ù. À̰͵éÀº ÁÖ·Î ÄÚ¸£Æ¼¼Õ(cortisone)(INN)¡¤È÷µå·ÎÄÚ¸£Æ¼¼Õ(hydrocortisone)(INN)¡¤ÇÁ·¹µå´Ï¼Õ(prednisone)(INN)°ú ÇÁ·¹µå´Ï¼Ö·Ð(prednisolone)(INN)ÀÇ À¯µµÃ¼µéÀÌ´Ù. À̰͵éÀº Ç׿°°ú Ç×·ù¸ÓƼÁòÁ¦·Î »ç¿ëÇÑ´Ù. (2) ÄÚ¸£Æ¼ÄÚ½ºÅ×·ÎÀ̵å(corticosteroid) È£¸£¸óÀÇ ÇҷΰÕÈ À¯µµÃ¼ : ÀϹÝÀûÀ¸·Î °í³ ¸µ(gonane ring)ÀÇ 6 À̳ª 9 À§Ä¡¿¡¼ ¼ö¼Ò¿øÀÚ´Â ¿°¼Ò³ª ºÒ¼Ò ¿øÀÚ[¿¹¸¦ µé¸é, µ¦»ç¸ÞŸÁ¸(dexamethasone)(INN)]¿¡ ÀÇÇؼ ´ëüµÇ°í ´çÁú ºÎ½ÅÇÇÁúÈ£¸£¸ó(ÄÚ¸£Æ¼ÄÚÀ̵å)°ú À̰͵鿡¼ À¯µµµÈ ÄÚ¸£Æ¼ÄÚÀ̵åÀÇ ¼Ò¿°ÀÛ¿ëÀ» Å©°Ô ³ôÀÌ´Â ½ºÅ×·ÎÀ̵åÀÌ´Ù. ÀÌ À¯µµÃ¼µéÀº ¿¡½ºÅ׸£¿Í ¾Æ¼¼Å䳪À̵å[¿¹¸¦ µé¸é, Ç÷ç¿À½Ã³ë·Ð ¾Æ¼¼Åä´Ïµå(fluocinolone acetonide)(INN)] µîÀÇ ÇüÅ·ΠÁ¾Á¾ ´õ º¯ÇüµÇ¾î ÆǸŵȴÙ. (3) ¿¡½ºÆ®·Î°Õ(oestrogen)°ú ÇÁ·Î°Ô½ºÅä°Õ(progestogen) : À̵éÀº ³²¼º°ú ¿©¼º »ý½Ä±âµé¿¡ ÀÇÇؼ ºÐºñµÇ´Â ¼º È£¸£¸óµé ÁßÀÇ ÁÖ¿äÇÑ µÎ ±×·ìÀÌ´Ù. À̰͵éÀº ÇÕ¼ºÇÔÀ¸·Î½á ¾òÀ» ¼ö ÀÖ´Ù. ÀÌ È£¸£¸óÀº ÇÁ·Î°Ô½ºÆ¾°ú °Ô½ºÅ¸°ÕÀ¸·Î ºÒ¸°´Ù. ¿¡½ºÆ®·Î°Õ(oestrogen) : ³¼Ò¡¤°íȯ¡¤ºÎ½Å¡¤ÅÂ¹Ý ±×¸®°í ´Ù¸¥ ½ºÅ×·ÎÀ̵带 »ý¼ºÇÏ´Â Á¶Á÷µé¿¡ ÀÇÇؼ »ý¼ºµÇ´Â ¿©¼º È£¸£¸óÀÌ´Ù. ±×°ÍÀº ¾ÏÄÆ Æ÷À¯µ¿¹°¿¡¼ ¹ßÁ¤Çϵµ·Ï Çϴ Ư¡ÀÌ ÀÖ´Ù. ¿¡½ºÆ®·Î°ÕÀº ¿©¼º¼ºµéÀÌ ¹ßÇöµÇ°Ô ÇÏ°í Æó°æ±â Ä¡·áÁ¦³ª ÇÇÀÓ¾àÀÇ Á¶Á÷Ç¥º»À¸·Î »ç¿ëÇÑ´Ù. À̰͵éÀº ¾Æ·¡ÀÇ ¿¡½ºÆ®·Î°Õ¡¤À¯µµÃ¼ ±×¸®°í À¯»çü¸¦ Æ÷ÇÔÇÑ´Ù. (a) ¿¡½ºÆ®·Ð(estrone)(INN) : Àΰ£ÀÇ ÁÖ¿äÇÑ ¿¡½ºÆ®·Î°Õ (b) ¿¡½ºÆ®¶óµð¿Ã(estradiol)(INN) : Áß¿äÇÑ Ãµ¿¬ ¿¡½ºÆ®·Î°Õ (c) ¿¡½ºÆ®¸®¿Ã(estriol)(INN) : ÀÚ¿¬ ¿¡½ºÆ®·Î°Õ (d) ¿¡Æ¼´Ò ¿¡½ºÆ®¶óµð¿Ã(ethinyl estradiol)(INN) : ÀÔÀ» ÅëÇؼ È°µ¿¼ºÀÌ ÀÖ°í Á¶ÇÕ ±¸° ÇÇÀӾ࿡¼ ÁÖ¿ä ¿¡½ºÆ®·Î°Õ ¼ººÐÀ¸·Î »ç¿ëÇÏ´Â Áß¿äÇÑ ÇÕ¼º ¿¡½ºÆ®·Î°Õ (e) ¸Þ½ºÆ®¶ó³î(mestranol)(INN) : ¿¡Æ¼´Ò ¿¡½ºÆ®¶óµð¿Ã(ethinyl estradiol)ÀÇ ¿¡Å׸£(ether) À¯µµÃ¼. ±¸° ÇÇÀÓ¾àÀ¸·Î »ç¿ëÇÑ´Ù. ÇÁ·Î°Ô½ºÅä°Õ(progestogen) : ±×°ÍµéÀÇ ÀÓ½ÅÀüÀÇ È¿°ú¸¦ °í·ÁÇÏ¿© ¸í¸íµÈ ½ºÅ×·ÎÀ̵åµé ÁßÀÇ ÇÑ Á¾·ùÀε¥, ±×°ÍÀº ÀÓ½ÅÀ» ½ÃÀÛÇÏ°Ô ÇÏ°í Áö¼Ó½ÃÅ°´Âµ¥ ÇʼöÀûÀÌ´Ù. ÀÌ ¿©¼º È£¸£¸óµéÀº ÀÓ½ÅÀ» À§ÇÏ¿© ±×¸®°í ÀÓ½ÅÀ» Áö¼Ó½ÃÅ°±â À§ÇÏ¿© ÀÚ±ÃÀ» Áغñ½ÃŲ´Ù. ±×°ÍµéÀº ¹è¶õÀ» ¸·±â ¶§¹®¿¡, ¸¹Àº ÇÁ·ÎÁ¦½ºÆ¾ÀÌ ÇÇÀÓ¾àÀÇ ¼ººÐµé·Î¼ »ç¿ëÇÑ´Ù. À̰͵éÀº ´ÙÀ½À» Æ÷ÇÔÇÑ´Ù. (a) ÇÁ·Î°Ô½ºÅ×·Ð(progesterone)(INN)* : ü³»ÀÇ Á¦1±â ÇÁ·Î°Ô½ºÆ¾ÀÌ¸ç ¿¡½ºÆ®·Î°Õ¡¤¾Èµå·Î°Õ°ú ÄÚ¸£Æ¼ÄÚ½ºÅ×·ÎÀ̵å(corticosteroid)ÀÇ »ýÈÇÕ °úÁ¤¿¡¼ÀÇ Áß°£¹°. ±×°ÍÀº ³ÀÚ ¹æÃâ ÈÄ È²»öü¿¡ ÀÇÇؼ »ý¼ºµÇ°í ºÎ½Å¡¤Å¹ݡ¤°íȯ¿¡¼ »ý¼ºµÈ´Ù. (b) ÇÁ·¹±×³µð¿Ã(pregnandiol) : ÇÁ·Î°Ô½ºÅ׷к¸´Ù ÈξÀ ´õ ¾àÇÑ »ý¹°ÇÐÀû È°¼ºµµ¸¦ °®°í Àִ õ¿¬ÀûÀ¸·Î »ý±â´Â ÇÁ·Î°Ô½ºÆ¾ (4) ±× ¹ÛÀÇ ½ºÅ×·ÎÀ̵å È£¸£¸ó ¾Èµå·Î°Õ(androgen) : À§¿¡ Æ÷ÇÔµÇÁö ¾ÊÀº ¼ºÈ£¸£¸óÀÇ Áß¿äÇÑ ±×·ìÀ̸ç ÁÖ·Î °íȯ¿¡¼ »ý¼ºµÇ¸ç ³¼Ò, ºÎ½ÅÇÇÁú°ú Źݿ¡¼ ÀûÀº ¾çÀÌ »ý¼ºµÈ´Ù. ¾Èµå·Î°ÕÀº ³²¼º ¼ºÀ» Çü¼ºÇÏ´Â ¿ªÇÒÀ» ÇÑ´Ù. ¾Èµå·Î°ÕÀº ½ÅÁø´ë»ç µî¿¡ ¿µÇâÀ» ¹ÌÄ¡¸ç µ¿ÈÀÛ¿ëÀ» ÇÑ´Ù. Å×½ºÅ佺Å×·Ð(testosterone)(INN)Àº °¡Àå Áß¿äÇÑ ¾Èµå·Î°Õµé Áß ÇϳªÀÌ´Ù. ÀÌ ºÎºÐÀº ¶ÇÇÑ Ç׿¡½ºÆ®·Î°Õ¡¤Ç׾ȵå·Î°Õ°ú Ç×ÇÁ·Î°Ô½ºÅ×·Ð(Ç×ÇÁ·Î°Ô½ºÆ¾¡¤Ç׿¡½ºÅ¸°Õ)°ú °°Àº È£¸£¸óÀÇ ¿µÇâÀ» ¾ïÁ¦Çϰųª ¹æÇØÇϴµ¥ »ç¿ëÇÏ´Â ÇÕ¼º ½ºÅ×·ÎÀ̵åµéÀ» Æ÷ÇÔÇÑ´Ù. ½ºÅ×·ÎÀ̵å Ç×ÇÁ·Î°Ô½ºÆ¾Àº ¸î¸îÀÇ ´ç´¢º´ Ä¡·á¿¡ ¸¹ÀÌ »ç¿ëÇÏ´Â ÇÁ·Î°Ô½ºÆ¾ ±æÇ×Á¦ÀÌ´Ù. ¿¹¸¦ µé¸é, ÀÌ ±×·ì¿¡´Â ¿À³ªÇÁ¸®½ºÅæ(onapristone)(INN)°ú ¾Æ±Û·¹ÇÁ¸®½ºÅæ(aglepristone)(INN)À» Æ÷ÇÔÇÑ´Ù. ÀÌµé ½ºÅ×·ÎÀ̵å Áß ±¹Á¦¹«¿ª»ó Áß¿äÇÑ °ÍÀº ´ÙÀ½ Ç¥¿Í °°´Ù. º» Ç¥´Â ±× ¹°Ç°ÀÇ ¾à¸íÀ» ¾ËÆĺª¼øÀ¸·Î ±âÀçÇÏ¿´°í ±× ÁÖµÈ È£¸£¸ó ÀÛ¿ëÀ» Ç¥½ÃÇÏ¿´´Ù. »ç¿ëÇÑ Ç°¸íÀº WHO¿¡¼ °øÇ¥ÇÑ International Nonproprietary Names for pharmaceutical preparations(INN)³ª International Nonproprietary Names Modified(INNM)¿¡ ÀÇÇÏ¿´À¸¸ç, ÈÇиíÀº IUPACÀÇ 1957³â ½ºÅ×·ÎÀ̵å Ç°¸ñºÐ·ù±ÔÁ¦¿¡ ÀÇÇÑ °ÍÀÌ´Ù. ÁַΠȣ¸£¸ó ±â´ÉÀ¸·Î »ç¿ëÇÏ´Â ½ºÅ×·ÎÀ̵åÀÇ À϶÷Ç¥ ¾à¸í / ÈÇиí / ÁÖÈ£¸£¸ó±â´É Adrenosterone / androst-4-ene-3,11,17-trione / Androgen Aldosterone (INN) / 11¥â,21-dihydroxy-3,20-dioxopregn-4-en-18-al / Corticosteroid Allylestrenol (INN) / 17¥á-allyloestr-4-en-17¥â-ol / Progestogen (No short name) / 5¥á-androstane-3,17-dione / Androgen intermediate Androstanolone (INN) / 17¥â-hydroxy-5¥á-androstan-3-one / Androgen Androstenediols / androst-5-ene-3¥â,17¥â-diol, androst-5-ene-3¥â,17¥â-diol / Anabolic intermediate (No short name) / androst-4-ene-3,17-dione / Androgen intermediate Androsterone / 3¥á-hydroxy-5a-androstan-17-one / Androgen Betamethasone (INN) / 9¥á-fluoro-11¥â,17a,21-trihydroxy-16¥â-methylpregna-1,4-diene-3,20-dione / Corticosteroid Bolasterone (INN) / 17¥â-hydroxy-7¥á,17¥á-dimethylandrost-4-en-3-one / Anabolic Chlormadinone (INN) / 6-chloro-17¥á-hydroxypregna-4,6-diene-3,20-dione / Progestogen Chloroprednisone (INN) / 6¥á-chloro-17¥á,21-dihydroxypregna-1,4-diene-3,11,20-trione / Corticosteroid Clocortolone (INN) / 9¥á-chloro-6¥á-fluoro-11¥â,21-dihydroxy-16¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid Clostebol (INN) / 4-chloro-17¥â-hydroxyandrost-4-en-3-one / Anabolic Corticosterone / 11¥â,21-dihydroxypregn-4-ene-3,20-dione / Corticosteroid Cortisol - see Hydrocortisone Cortisone (INN) / 17¥á,21-dihydroxypregn-4-ene-3,11,20-trione / Corticosteroid 11-Dehydrocorticosterone / 21-hydroxypregn-4-ene-3,11,20-trione / Corticosteroid Deoxycorticosterone - see Desoxycortone Desoxycortone (INN) / 21-hydroxypregn-4-ene-3,20-dione / Corticosteroid Dexamethasone (INN) / 9¥á-fluoro-11¥â,17¥á,21-trihydroxy-16¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid Dihydroandrosterone / 5¥á-androstane-3¥á,17¥â-diol / Androgen intermediate Dydrogesterone (INN) / 9¥â,10¥á-pregna-4,6-diene-3,20-dione / Progestogen Equilenin / 3-hydroxyoestra-1,3,5(10),6,8-pentaen-17-one / Oestrogen Equilin / 3-hydroxyoestra-1,3,5(10),7-tetraen-17-one /Oestrogen / Estradiol (INN) / oestra-1,3,5(10)-triene-3,17¥â-diol / Oestrogen Estriol (INNM) / oestra-1,3,5(10)-triene-3,16¥á,17¥â-triol / Oestrogen Estrone (INN) / 3-hydroxyoestra-1,3,5(10)-trien-17-one / Oestrogen Ethinylestradiol (INN) / 17¥á-ethynyloestra-1,3,5(10)-triene-3,17¥â-diol / Oestrogen Ethisterone (INN) / 17¥á-ethynyl-17¥â-hydroxyandrost-4-en-3-one / Progestogen Ethylestrenol (INN) / 17¥á-ethyloestr-4-en-17¥â-ol / Anabolic Etynodiol (INN) / 17¥á-ethynyloestr-4-ene-3¥â,17¥â-diol / Progestogen Fludrocortisone (INN) / 9¥á-fluoro-11¥â,17¥á,21-trihydroxypregn-4-ene-3,20-dione/ Corticosteroid / Flumetasone (INN) / 6¥á,9¥á-difluoro-11¥â,17¥á,21-trihydroxy-16¥á-methylpregna-1,4-diene- 3,20-dione / Corticosteroid Fluocinolone (INNM) / 6¥á,9¥á-difluoro-11¥â,16¥á,17¥á,21-tetrahydroxy-pregna-1,4-diene-3,20-dione / Corticosteroid Fluocortolone (INN) / 6¥á-fluoro-11¥â,21-dihydroxy-16¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid Fluorometholone (INN) / 9¥á-fluoro-11¥â,17¥á-dihydroxy-6¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid 9¥á-Fluoroprednisolone / 9¥á-fluoro-11¥â,17¥á,21-trihydroxypregna-1,4-diene-3,20-dione / Corticosteroid Fluoxymesterone (INN) / 9¥á-fluoro-11¥â,17¥â-dihydroxy-17¥á-methylandrost-4-en-3-one / Androgen Fluprednidene (INN) / 9¥á-fluoro-11¥â,17¥á,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione / Corticosteroid Fluprednisolone (INN) / 6¥á-fluoro-11¥â,17¥á,21-trihydroxypregna-1,4-diene-3,20-dione / Corticosteroid Flurandrenolone / 6¥á-fluoro-11¥â,16¥á,17¥á,21-tetrahydroxypregn-4-ene-3,20-dione / Corticosteroid Formocortal (INN) / 3-(2-chloroethoxy)-9¥á-fluoro-6-formyl-11¥â,21-dihydroxy-16¥á,17-isopropylidenedioxypregna-3,5-dien-20 one 21-acetate / Corticosteroid Gestonorone (INNM) / 17¥â-ethyl-17¥á-hydroxyoestr-4-ene-3,20-dione / Progestogen Hydrocortisone (INN) / 11¥â,17¥á,21-trihydroxypregn-4-ene-3,20-dione / Corticosteroid Hydroxyprogesterone (INN) / 17¥á-hydroxypregn-4-ene-3,20-dione / Progestogen Lynestrenol (INN) / 17¥á-ethynyloestr-4-en-17¥â-ol / Progestogen Medroxyprogesterone (INN) / 17¥á-hydroxy-6¥á-methylpregn-4-ene-3,20-dione / Progestogen Megestrol (INN) / 17¥á-hydroxy-6-methylpregna-4,6-diene-3,20-dione / Progestogen Mestanolone (INN) / 17¥â-hydroxy-17¥á-methyl-5¥á-androstan-3-one / Anabolic Mesterolone (INN) / 17¥â-hydroxy-1¥á-methyl-5¥á-androstan-3-one / Androgen Mestranol (INN) / 17¥á-ethynyl-3-methoxyoestra-1,3,5(10)-trien-17¥â-ol / Oestrogen Metandienone (INN) / 17¥â-hydroxy-17¥á-methylandrosta-1,4-dien-3-one / Anabolic Metenolone (INN) / 17¥â-hydroxy-1-methyl-5¥á-androst-1-en-3-one / Anabolic Methandriol (INN) / 17¥á-methylandrost-5-ene-3¥â,17¥â-diol / Anabolic 2-Methylhydrocortisone / 11¥â,17¥á,21-trihydroxy-2¥â-methylpregn-4-ene-3,20-dione / Corticosteroid 6¥á-Methylhydrocortisone / 11¥â,17¥á,21-trihydroxy-6¥á-methylpregn-4-ene-3,20-dione / Corticosteroid Methylnortestosterone / 17¥â-hydroxy-17¥á-methyloestr-4-en-3-one / Progestogen 17¥á-Methyloestradiol / 17¥á-methyloestra-1,3,5(10)-triene-3,17¥â-diol / Oestrogen Methylprednisolone (INN) / 11¥â,17¥á,21-trihydroxy-6¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid Methyltestosterone (INN) / 17¥â-hydroxy-17¥á-methylandrost-4-en-3-one / Androgen Nandrolone (INN) / 17¥â-hydroxyoestr-4-en-3-one / Anabolic Norethandrolone (INN) / 17¥á-ethyl-17¥â-hydroxyoestr-4-en-3-one / Anabolic Norethisterone (INN) / 17¥á-ethynyl-17¥â-hydroxyoestr-4-en-3-one / Progestogen Noretynodrel (INN) / 17¥á-ethynyl-17¥â-hydroxyoestr-5(10)-en-3-one / Progestogen Norgestrel (INN) / 13¥â-ethyl-17¥á-ethynyl-17¥â-hydroxygon-4-en-3-one / Progestogen Normethandrone - see Methylnortestosterone Nortestosterone - see Nandrolone Oxabolone (INNM) / 4,17¥â-dihydroxyoestr-4-en-3-one / Anabolic Oxymesterone (INN) / 4,17¥â-dihydroxy-17¥á-methylandrost-4-en-3-one / Anabolic Oxymetholone (INN) / 17¥â-hydroxy-2-hydroxymethylene-17¥á-methyl-5¥á-androstan-3-one / Anabolic Paramethasone (INN) / 6¥á-fluoro-11¥â,17¥á,21-trihydroxy-16¥á-methylpregna-1,4-diene-3,20-dione / Corticosteroid Prasterone (INN) / 3¥â-hydroxyandrost-5-en-17-one / Androgen Prednisolone (INN) / 11¥â,17¥á,21-trihydroxypregna-1,4-diene-3,20-dione / Corticosteroid Prednisone (INN) / 17¥á,21-dihydroxypregna-1,4-diene-3,11,20-trione / Corticosteroid Prednylidene (INN) / 11¥â,17¥á,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione / Corticosteroid Pregnenolone (INN) / 3¥â-hydroxypregn-5-en-20-one / Corticosteroid Progesterone (INN) / pregn-4-ene-3,20-dione / Progestogen Stanolone - see Androstanolone Testosterone (INN) / 17¥â-hydroxyandrost-4-en-3-one / Androgen Tiomesterone (INN) / 1¥á,7¥á-di(acetylthio)-17¥â-hydroxy-17¥á-methylandrost-4-en-3-one / Anabolic Triamcinolone (INN) / 9¥á-fluoro-11¥â,16¥á,17¥á,21-tetrahydroxypregna-1,4-diene-3,20-dione / Corticosteroid(C) ÇÁ·Î½ºÅ¸±Û¶õµò(prostaglandin), Æ®·Òº¹»ê(thromboxane) ±×¸®°í ·ùÄÚÆ®¸®¿£(leukotriene)¡¤±× À¯µµÃ¼¿Í ±¸Á¶Àû À¯»çü ÀÌ »ý¼º¹°µéÀº ¾Æ¶óÅ°µ·»ê(arachidonic acid)ÀÇ À¯µµÃ¼´Ù. (1) ÇÁ·Î½ºÅ¸±Û¶õµò(prostaglandin) °¡Àå Áß¿äÇÑ ¾Æ¶óÅ°µ·»ê(arachidonic acid) À¯µµÃ¼´Â È£¸£¸óÀ¸·Î¼ ¹Ì¼Ò·®¿¡¼µµ ÀÛ¿ëÇÏ´Â ±×¸®°í ÇÁ·Î½ºÅ¸³ë»êÀÇ ±âº»ÀûÀÎ ±¸Á¶¸¦ Æ÷ÇÔÇÏ´Â ³»»ýÀû ¹°ÁúÀÎ ÇÁ·Î½ºÅ¸±Û¶õµò(prostaglandin)ÀÌ´Ù. ÇÁ·Î½ºÅ¸±Û¶õµòÀº Ç÷¾× ¼øȯ¡¤ÄáÆÏ ±â´É ±×¸®°í ¿£µå·ÎÅ©¸°(endrocrine) ü°è[¿¹¸¦ µé¸é Ȳü(üÜô÷)¿¡ ÀÇÇÑ ÇÁ·Î°Ô½ºÅ×·ÐÀÇ »ý¼ºÀ» ÁÙÀÓÀ¸·Î½á]ÀÇ Á¶Àý¿¡ ¿µÇâÀ» ³¢Ä¡¸ç; À̰͵éÀº ¶ÇÇÑ À¯¿¬ÇÑ ±ÙÀ°ÀÇ ¼öÃà ȤÀº Ç÷°üÀÇ È®ÀåÀ» ÀÚ±ØÇÏ°í Ç÷¼ÒÆÇ ÀÀÁýÀ» ¸·À¸¸ç À§¼±ºÐºñ¸¦ Á¶ÀýÇÑ´Ù. À̰͵éÀº ¾Æ·¡ÀÇ ÇÁ·Î½ºÅ¸±Û¶õµò¡¤À¯µµÃ¼ ±×¸®°í ±¸Á¶Àû À¯»çü¸¦ Æ÷ÇÔÇÑ´Ù. (a) ¾ËÇÁ·Î½ºÅ¸µô(alprostadil)(INN)(ÇÁ·Î½ºÅ¸±Û¶õµò E1) : »ý¹°ÇÐÀû ÃßÃâ¹°(extract) µî¿¡¼ °áÁ¤ÈµÈ 1±â ÇÁ·Î½ºÅ¸±Û¶õµòÀÌ´Ù. ÀÌ°ÍÀº Ç÷°üÈ®ÀåÁ¦·Î »ç¿ëÇÑ´Ù. ÀÌ°ÍÀº ¶ÇÇÑ ÄáÆÏ ²®Áú¿¡¼ ¿¡¸®Æ®·ÎÆ÷¿¡Æ¾ÀÇ ¹æÃâÀ» ÀÚ±ØÇÏ´Â ±â´ÉÀ» ÇÏ°í Ç÷¾× Ç÷¼ÒÆÇ ÀÀÁýÀ» ¾ïÁ¦ÇÑ´Ù. 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