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29.35 - Sulphonamides

Sulphonamides have the general formula (R1SO2NR2R3) where R1 is an organic radical of varying complexity having a carbon atom directly attached to the SO2 group and R2 and R3 are either : hydrogen, another atom or an inorganic or organic radical of varying complexity (including double bonds or rings). Many are used in medicine as powerful bactericides. They include, inter alia :

(1) N-Alkylperfluorooctane sulphonamides*. Examples are N-methylperfluorooctane sulphonamide or N-ethyl-N-(2-hydroxyethyl) perfluorooctane sulphonamide. These chemicals break down to form perfluorooctane sulfonate (PFOS) (see also headings 29.04, 29.22, 29.23, 38.08 and 38.24).

(2) o-Toluenesulphonamide.

(3) o-Sulphamoylbenzoic acid.

(4) p-Sulphamoylbenzylamine.

(5) p-Aminobenzenesulphonamide (H2NC6H4SO2NH2) (sulphanilamide)*.

(6) p-Aminobenzenesulphonacetamide.

(7) Sildenafil citrate.

(8) Sulphapyridine (INN) or p-aminobenzenesulphonamidopyridine.

(9) Sulphadiazine (INN) or p-aminobenzenesulphonamidopyrimidine.

(10) Sulphamerazine (INN) or p-aminobenzenesulphonamidomethylpyrimidine.

(11) Sulphathiourea (INN) or p-aminobenzenesulphonamidothiourea.

(12) Sulphathiazole (INN) or p-aminobenzenesulphonamidothiazole.

(13) Chlorinated sulphonamides whether or not the chlorine atom is directly linked to nitrogen (e.g., sulphonchloramides or N-chlorosulphonamides, known as "chloramines";
"chloro¡©thiazide" or 6-chloro-7-sulphamoylbenzo-1,2,4-thiadiazine 1,1-dioxide; 6-chloro-3,4-dihydro-7-sulphamoylbenzo-1,2,4-thiadiazine 1,1-dioxide).

This heading excludes compounds in which all of the S-N bonds of the sulphonamide group(s) are part of a ring. They are other heterocyclic compounds (sultams) of heading 29.34.

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